Disease monitoring with OCT in birdshot chorioretinitis under systemic therapy
Accept poster if oral is not possible ?
Yes
Purpose
To observe the role of optical coherence tomography (OCT) in monitoring patients with BC.
Methods
A retrospective observational case series identified 4 patients (8 eyes) diagnosed with BC according to the SUN criteria, that were managed by a single uveitis specialist and treated with local or systemic therapy. All patients were submitted to routine ophthalmological examination, LFP (Kowa FM 600), OCT (Copernicus REVO NX), dual angiography (HRA2, Heidelberg Engineering) and ERG.
Results
Two patients (4 eyes) were treated with local corticosteroid therapy. In these cases, the ganglion cell layer (GCL) thickness decreased in the first patient by 4 and 5, in the second - by 3 and 1 μm/year, and the average peripapillary retinal nerve fiber thickness (RNFL) in the first by 10% and 13% over 32 months (6 and 5 μm/year), in the second - by 1% and 7% over 30 months (1 and 2 μm/year).
Two other patients agreed to systemic therapy, one received systemic prednisolone (1 mg/kg/day) and mycophenolate mofetil (3000 mg/day), and then was transferred to rituximab from 04/24. Stabilization of the GCL and RNFL thickness was established only after switching to the latter drug - GCL: -3 and +9, RNFL: 0 and +12 μm (for 7.5 months). The second patient was switched to adalimumab in 07/23, and only minor decreases in GCL (1 and 2 μm over 16 months) and RNFL (3 and 0 μm over 16 months) thickness were observed with this therapy.
Conclusion
OCT is a convenient method for monitoring patients with BC. It is most likely, that biological therapy can lead to stabilization of GCL and RNFL thickness in BC, but further research is needed.
Conflict of interest
No
1
Last name
KUZNETCOVA
Initials of first name(s)
T.I.
Department
I.P. Pavlov First St.Petersburg State Medical University, Y.S. Astakhov Ophthalmology Department
City
St.Petersburg
Country
Russian Federation
2
Last name
Astakhov
Initials of first name(s)
S.Y.
Department
I.P. Pavlov First St.Petersburg State Medical University, Y.S. Astakhov Ophthalmology Department
City
St.Petersburg
Country
Russian Federation
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