Comparisons of choroidal blood flow velocity between initial-onset acute uveitis associated with Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy
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No
Purpose
Acute central serous chorioretinopathy (CSC) and Vogt-Koyanagi-Harada (VKH) disease in the acute uveitic phase are characterized by serous retinal detachment caused by dysfunction of the choroid. The aim of this study is to compare blood flow velocity and pulse waveform parameters in the choroid between these two diseases.
Methods
In this study, 25 patients (50 eyes) with VKH disease, 21 patients (27 eyes) with CSC and 15 healthy controls (30 eyes) were studied. Laser speckle flowgraphy (LSFG) was performed at presentation.
Results
Choroidal mean blur rate (MBR), representing blood flow velocity in choroidal vessels, was significantly lower in the eyes affected by VKH disease compared with the healthy control and CSC eyes. CSC eyes had a significantly higher MBR compared with healthy controls. Among the analyzed pulse waveform parameters, blow-out time (BOT), falling rate (FR) and flow acceleration index (FAI) changed significantly. BOT value was significantly lower in CSC eyes than in healthy control and VKH eyes. FR and FAI values were significantly lower in VKH eyes than in healthy control and CSC eyes. There was a strong positive correlation between MBR and FAI.
Conclusion
Our findings confirm different pathophysiology of these two diseases. Assessment of choroidal blood flow velocity and haemodynamics with LSFG provides useful information to differentiate acute CSC and initial-onset acute uveitis associated with VKH disease.
Conflict of interest
No
1
Last name
ABU EL-ASRAR
Initials of first name(s)
A
Department
Ophthalmology, King Saud University
City
Riyadh
Country
Saudi Arabia
2
Last name
Albloushi
Initials of first name(s)
A
Department
Ophthalmology, King Saud University
City
Riyadh
Country
Saudi Arabia
3
Last name
Abouammoh
Initials of first name(s)
M
Department
Ophthalmology, King Saud University
City
Riyadh
Country
Saudi Arabia
4
Last name
Alzubaidi
Initials of first name(s)
A
Department
Ophthalmology, King Saud University
City
Riyadh
Country
Saudi Arabia
5
Last name
Gikandi
Initials of first name(s)
P
Department
Ophthalmology, King Saud University
City
Riyadh
Country
Saudi Arabia
6
Last name
Al Faran
Initials of first name(s)
A
Department
Ophthalmology, King Saud University
City
Riyadh
Country
Saudi Arabia
7
Last name
Al-Kharashi
Initials of first name(s)
A
Department
Ophthalmology, King Saud University
City
Riyadh
Country
Saudi Arabia
8
Last name
Al-Dahmash
Initials of first name(s)
S
Department
Ophthalmology, King Saud University
City
Riyadh
Country
Saudi Arabia
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