Supportive role of Anterior Segment Optical Coherence Tomography in Uveitis-Glaucoma-Hyphema Syndrome
Purpose
To analyse the clinical features of patients diagnosed with uveitis-glaucoma-hyphema (UGH) syndrome and to evaluate the supportive diagnostic role of anterior segment optical coherence tomography (AS-OCT).
Methods
Retrospective retrieval of data incorporating all new UGH syndrome cases evaluated at the Ocular Immunology Unit in Reggio Emilia (Italy) from January 2019 to December 2022.
Results
All the 22 patients were Caucasian; 12 (54.5%) were male. The mean age at symptom onset was 59 (range 7-86) years. The mean (± standard deviation) time between cataract surgery and symptom onset and between symptom onset and UGH syndrome diagnosis were 93.9 (±77,3) and 15.2 (±14.8) months, respectively. Fifty percent of the patients had been erroneously diagnosed with idiopathic anterior uveitis and 22.7% with herpetic anterior uveitis. The most frequent clinical features were iris atrophy (63.6%), anterior chamber inflammation (59.1%), ocular hypertension (54.5%), vitreous involvement (50%) and IOL subluxation (45.5%). The majority of patients (90.9%) presented with intraocular lens (IOL) located in the ciliary sulcus, and one-piece was the most common IOL type (72.7%). All patients underwent AS-OCT, which showed a disruption of the normal reflectivity of the posterior iris surface due to iris-IOL contact.
Conclusion
In pseudophakic subjects affected by recurrent intraocular inflammation, UGH syndrome should be considered in the differential diagnosis. In these cases, AS-OCT is a rapid, non-invasive way to confirm the diagnosis.
Conflict of interest
No
Authors 1
Last name
DE SIMONE
Initials of first name(s)
L.
Department
OCULAR IMMUNOLOGY UNIT - AZIENDA USL-IRCCS DI REGGIO EMILIA
City
Reggio Emilia
Country
Italy
Authors 2
Last name
GENTILE
Initials of first name(s)
P.
Department
OCULAR IMMUNOLOGY UNIT - AZIENDA USL-IRCCS DI REGGIO EMILIA
City
REGGIO EMILIA
Country
Italy
Authors 3
Last name
BOLLETTA
Initials of first name(s)
E.
Department
OCULAR IMMUNOLOGY UNIT - AZIENDA USL-IRCCS DI REGGIO EMILIA
City
REGGIO EMILIA
Country
Italy
Authors 4
Last name
GOZZI
Initials of first name(s)
F.
Department
OCULAR IMMUNOLOGY UNIT - AZIENDA USL-IRCCS DI REGGIO EMILIA
City
REGGIO EMILIA
Country
Italy
Authors 5
Last name
CIMINO
Initials of first name(s)
L.
Department
OCULAR IMMUNOLOGY UNIT - AZIENDA USL-IRCCS DI REGGIO EMILIA
City
REGGIO EMILIA
Country
Italy
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