Corneal endotheliopathy associated with peadiatric uveitis : A case series
Purpose
To describe the finding of inferior corneal haze in pedriatic uveitis.
Methods
Retrospective observational case-series
Results
There were 6 patients including 4 females and 2 males diagnosed with uveitis. Age ranged from 2 to 16 years.
Uveitis was bilateral in 5 cases and unilateral in one patient. Corneal examination revealed inferior endothelial opacity in five eyes, endothelial fibrinous deposits in two eyes, deep stromal opacity in one eye and subendothelial opacity in one eye.
Associated ocular findings included granulomatous keratic precipitates (n=7 eyes), fine keratic precipitates (n=2 eyes), posterior synechiae (5 eyes), iris nodules (n=2), vitreous opacities (1 eye), snowballs (1 eye) and snowbank (1 eye).
Fluorescein angiography showed bilateral segmental and focal peripheral vasculitis in one case. OCT showed cystoid macular edema in one eye.
The diagnosis of presumed sarcoidosis was made in 4 cases and parsplanitis in 2 cases.
Treatment modalities included topical corticosteroids (n=7), oral corticosteroids (n=3), laterobulbar corticosteroids injection (n=1), and systemic Methotrexate (n=2) .
The corneal opacity resolved completely under treatment in 4/9 eyes, and partially in 1/9 eye.
Conclusion
Corneal involvement including stromal and endothelial opacities is attributed to autoimmune endothelipathy. It has been associated with parsplanitis and others causes of pediatric uveitis. Corneal haze may resolve under treatment or lead to localized corneal scars and photophobia.
Conflict of interest
No
Authors 1
Last name
MAHJOUB
Initials of first name(s)
A
Department
Department of ophthalmology, Fattouma Bourguiba University Hospital, Monastir, Tunisia
City
MONASTIR
Country
Tunisia
Authors 2
Last name
ABROUG
Initials of first name(s)
N
Department
Department of ophthalmology, Fattouma Bourguiba University Hospital, Monastir, Tunisia
City
MONASTIR
Country
Tunisia
Authors 3
Last name
ALLAGUI
Initials of first name(s)
O
Department
Department of ophthalmology, Fattouma Bourguiba University Hospital, Monastir, Tunisia
City
MONASTIR
Country
Tunisia
Authors 4
Last name
LOUKIL
Initials of first name(s)
H
Department
Department of ophthalmology, Fattouma Bourguiba University Hospital, Monastir, Tunisia
City
MONASTIR
Country
Tunisia
Authors 5
Last name
JELLITI
Initials of first name(s)
B
Department
Department of ophthalmology, Fattouma Bourguiba University Hospital, Monastir, Tunisia
City
MONASTIR
Country
Tunisia
Authors 6
Last name
KHAIRALLAH
Initials of first name(s)
M
Department
Department of ophthalmology, Fattouma Bourguiba University Hospital, Monastir, Tunisia
City
MONASTIR
Country
Tunisia
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