Non-infectious uveitis treated with 0,19 mg fluocinolone acetonide intravitreal implant (ILUVIEN®): a real-world case series
Purpose
Assess the effectiveness and safety profile of 0,19 mg fluocinolone acetonide intravitreal implant (FAc; ILUVIEN®) in patients with uveitis in the clinical practice.
Methods
Retrospective case-series analysis of 8 eyes (4 patients) with non-infectious uveitis.
Results
This analysis included: 6 eyes with idiopathic panuveitis and 2 with rheumatoid arthritis-associated uveitis, with a mean±standard deviation follow-up time post-FAc of 16±8 months. At baseline 75% presented macular edema, 75% posterior synechia, 25% glaucoma and 63% were phakic (1 eye with cataract). In 38% eyes the last treatment prior FAc implant was dexamethasone implant. At baseline, 63% were under topical treatment and 50% under systemic therapy. Median visual acuity was 62±24 letters, central retinal thickness (CRT) was 367±116 µm and intraocular pressure (IOP) was 13±3 mmHg. Regarding intraocular inflammation (IOI): 25% and 50% of eyes had a A/C cells and VH, respectively. Post-FAc implantation the visual acuity improved +15 letters (p< 0.05), anatomically eyes reached a median of 303±56 µm (p> 0.05), and in terms of IOI, 88% and 100% eyes achieved an A/C cells and VH grade 0, respectively. None needed supplemental intravitreal therapy post-FAc and, versus baseline, 80% and 50% of eyes had a topical and systemic therapy -sparing effect, respectively. thirteen percent of eyes were treated with emergent IOP-lowering medications and 3 eyes (60%) underwent cataract surgery
Conclusion
In this case series FAc showed benefit in the control of active intraocular inflammation: with most of eyes having visual acuity gain, improvement of macular edema, topical and systemic therapy sparing effect.
Conflict of interest
No
Authors 1
Last name
BESELGA
Initials of first name(s)
D
Department
Ophtalmology Department - Centro Hospitalar Barreiro Montijo, Portugal
City
Barreiro
Country
Portugal
Authors 2
Last name
Martins
Initials of first name(s)
L
Department
Ophtalmology Department - Centro Hospitalar Barreiro Montijo, Portugal
City
Barreiro
Country
Portugal
Authors 3
Last name
Ribeiro
Initials of first name(s)
MJ
Department
Ophtalmology Department - Centro Hospitalar Barreiro Montijo, Portugal
City
Barreiro
Country
Portugal
Authors 4
Last name
Borges
Initials of first name(s)
B
Department
Ophtalmology Department - Centro Hospitalar Barreiro Montijo, Portugal
City
Barreiro
Country
Portugal
Authors 5
Last name
Pedrosa
Initials of first name(s)
C
Department
Ophtalmology Department - Centro Hospitalar Barreiro Montijo, Portugal
City
Barreiro
Country
Portugal
Authors 6
Last name
Marreiros
Initials of first name(s)
M
Department
Ophtalmology Department - Centro Hospitalar Barreiro Montijo, Portugal
City
Barreiro
Country
Portugal
Authors 7
Last name
Francisco
Initials of first name(s)
D
Department
Ophtalmology Department - Centro Hospitalar Barreiro Montijo, Portugal
City
Barreiro
Country
Portugal
Authors 8
Last name
Portela
Initials of first name(s)
D
Department
Ophtalmology Department - Centro Hospitalar Barreiro Montijo, Portugal
City
Barreiro
Country
Portugal
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