Colombian Uveitis Multicentric Study (COL-UVEA): Clinical features of uveitis and clinical risk factors for vision impairment.
Purpose
To describe the clinical characteristics of uveitis in 9 different centers and determine the risk factors for visual impairment.
Methods
A cross-sectional study reviewing clinical records of patients attending nine ophthalmological centers in five cities in Colombia.
Results
3.404 patients were studied; 54.4% were women. The average age of the first episode was 39.75 (20.35). The mean visual acuity at its worst was 0.92 (0.92) LogMar. The most common characteristics were anterior uveitis (49.4%), with an acute course (48.7%), and non-granulomatous (83.9%). Uveitis was infectious primarily (37.8%), and the most frequent etiology was idiopathic (29.6%), followed by toxoplasmosis (25.3%). The adjusted multivariate analysis for visual impairment showed that patients of 0-9 years had an OR of 2.20 (95% CI 1.10-4.41, P=0.025). Likewise, patients with posterior uveitis had an OR of 1.82 (95% CI 1.38-2.39, P<0.001), and those with panuveitis had an OR of 2.02 (95% CI 1.58-2.59, P<0.001). Also, acute uveitis, had an OR of 1.35 (95% CI 1.07-1.70, P=0.010). Regarding complications, retinal detachment presented an OR of 2.76 (95% CI 1.88-4.14, P<0.001), band keratopathy had an OR of 2.49 (95% CI 1.10-6.37, P=0.039), and glaucoma had an OR of 1.97 (95% CI 1.42-2.77, P<0.001).
Conclusion
Children between 0 to 9 years old are at a greater risk of developing visual impairment, which has been related to posterior uveitis and panuveitis, with a granulomatous type of inflammation and an acute course. Also, the principal complications that lead to visual impairment are retinal detachment, band keratopathy, and glaucoma.
Conflict of interest
No
Authors 1
Last name
DE-LA-TORRE
Initials of first name(s)
ADLT
Department
Neuroscience Research Group (NEUROS), Universidad del Rosario
City
BOGOTÁ
Country
Colombia
Authors 2
Last name
CIFUENTES-GONZÁLEZ
Initials of first name(s)
CCG
Department
Neuroscience Research Group (NEUROS), Universidad del Rosario
City
BOGOTÁ
Country
Colombia
Authors 3
Last name
ROJAS-CARABALI
Initials of first name(s)
WARC
Department
Neuroscience Research Group (NEUROS), Universidad del Rosario
City
BOGOTÁ
Country
Colombia
Authors 4
Last name
CUEVAS
Initials of first name(s)
MC
Department
Department of Ophthalmology, Universidad de Antioquia
City
MEDELLÍN
Country
Colombia
Authors 5
Last name
GARCÍA
Initials of first name(s)
SG
Department
Department of Ophthalmology, Universidad Pontificia Javeriana
City
CALI
Country
Colombia
Authors 6
Last name
RANGEL
Initials of first name(s)
CMR
Department
Department of Ophthalmology, Universidad Industrial de Santander
City
BUCARAMANGA
Country
Colombia
Authors 7
Last name
DURÁN
Initials of first name(s)
CD
Department
Ocular Immunology and Uveitis Department, Universidad CES
City
MEDELLÍN
Country
Colombia
Authors 8
Last name
PACHÓN-SUAREZ
Initials of first name(s)
DIPS
Department
Neuroscience Research Group (NEUROS), Universidad del Rosario
City
BOGOTÁ
Country
Colombia
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