Expression of matrix metalloproteinases (MMPs) in human intraocular lymphoma
Purpose
The purpose of this study is to investigate matrix metalloproteinases (MMPs) expression in human intraocular lymphoma (IOL).
Methods
Two enucleated eyes, 7 cell-block samples, and 25 samples of vitreous fluids obtained from patients with IOL who underwent vitrectomy were examined. Immunopathological examinations were performed for detection of MMP-2, MMP-9, and TIMP-4 expressions in enucleated eyes and cell-block samples. Protein concentrations of MMP-2 and MMP-9 were measured using the multiplex bead array assay in vitreous fluids.
Results
In the enucleated eye with primary IOL (PIOL), MMP-2 was negative, and MMP-9 and TIMP-4 were positive in lymphoma cells, while in the enucleated eye with secondary IOL (SIOL), all of the molecules were positive. Among cell-block samples with PIOL, the positive rate in lymphoma cells of MMP-2, MMP-9, and TIMP-4 was 75, 100, and 75%, respectively. In cell-block samples with SIOL, the positive rate of MMP-2, MMP-9, and TIMP-4 were all 100%. Intravitreal MMP-2 concentrations were significantly higher in SIOL than in PIOL, while there was no significant difference on MMP-9 concentrations.
Conclusion
These results suggest that MMPs may play an important role in the pathogenesis of IOL, especially in the metastasis.
Conflict of interest
No
Authors 1
Last name
KASE
Initials of first name(s)
S
Department
Ophthalmology
City
Sapporo
Country
Japan
Authors 2
Last name
Namba
Initials of first name(s)
K
Department
Ophthalmology
City
Sapporo
Country
Japan
Authors 3
Last name
Suzuki
Initials of first name(s)
K
Department
Ophthalology
City
Sapporo
Country
Japan
Authors 4
Last name
Fukutsu
Initials of first name(s)
K
Department
Ophthalmology
City
Sapporo
Country
Japan
Authors 5
Last name
Ishida
Initials of first name(s)
S
Department
Ophthalmology
City
Sapporo
Country
Japan
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