Quantitative Evaluation of Retinal Capillary Plexuses and Choriocapillaris in Posterior Uveitis Using Optical Coherence Tomography Angiography
Purpose
The aim of this study was to investigate quantitatively retinal capillary plexuses and choriocapillaris flow parameters in posterior uveitis without macular edema using spectral-domain optical coherence tomography angiography (SD-OCTA)
Methods
This is a single-center, cross-sectional, observational case series. 71 eyes affected with chronic non-infectious posterior uveitis or panuveitis without macular edema and 46 healthy controls underwent SD-OCTA imaging. The metrics calculated include vessel density of superficial, intermediate, and deep capillary plexuses, choriocapillaris blood flow area, foveal avascular zone area, diameter, and vascular density. We conducted a correlation analysis to assess the association between LogMAR best-corrected visual acuity and OCTA parameters.
Results
In comparison with healthy eyes, the eyes suffering from posterior or panuveitis without macular edema presented significantly lower vessel densities in deep (p<0.001) and intermediate capillary plexuses (p<0.001) and lower foveal avascular zone vascular density (p= 0.002). There was no statistical difference in the superficial capillary plexus or choriocapillaris blood flow area (p> 0.05). Additionally, we found no significant correlation between best-corrected visual acuity and any of the parameters.
Conclusion
Quantitative measurements by SD-OCTA reveal that patients suffering from posterior and panuveitis without macular edema have significantly reduced deep and intermediate capillary plexus vascular densities and foveal vascular density, without a significant reduction in choriocapillaris blood flow area, compared to healthy controls.
Conflict of interest
No
Authors 1
Last name
RIGO
Initials of first name(s)
S
Department
Ophthalmology, CHR Citadelle
City
Liège
Country
Belgium
Authors 2
Last name
MASSAMBA
Initials of first name(s)
N
Department
Ophthalmology, Pitié Salpêtrière Hospital
City
Paris
Country
France
Authors 3
Last name
BODAGHI
Initials of first name(s)
B
Department
Ophthalmology, Pitié Salpêtrière Hospital
City
Paris
Country
France
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