This abstract is assigned to sessions
| Presentation preference | Oral presentation |
| Title | Clinical and Virological Characteristics and Prognostic Factors in Viral Necrotizing Retinitis |
| Purpose | To describe the clinical and virological characteristics of viral necrotizing retinitis and assess the factors predicting the occurrence of retinal detachment or poor visual outcome(ie.best corrected visual acuity ≥0.7logMAR at 1month of surgery). |
| Methods | Retrospective study of all consecutive VNR patients diagnosed and monitored by qPCR on aqueous humor between 2015 and 2019.All patients received≥1intravenous antiviral therapy followed by oral antivirals+/-intravitreal injections of antiviral agents. |
| Results | 41 of 37patients of mean age 56years were included.Involved viruses were VZV(44%),CMV(37%)and HSV2 (19%).ARN represented 51%,PORN 12% and CMV retinitis 37% of included eyes.46 percent of patients were immunocompromised.Mean BCVA was 0.98 logMar at baseline and 1.05 logMar after an average of 14.1 months [range: 1-39].VNR bilateralized in 34% of cases after an average of 32 months [range: 0-96].RD occurred in 27% of cases after an average of 98 days [range: 0-330].Factors associated with poor visual outcome were: advanced age, low baseline BCVA, high grade of baseline vitritis, high baseline viral load and a "slow responder" status (ie.VL decrease<50% after 2 +/-1 weeks of IV antivirals).Factors associated with RD occurrence were:advanced age, immunocompetent status, low baseline BCVA, high baseline vitritis, and the use of > 5 IVIs. |
| Conclusion | VNR is a sight-threatening condition whose outcomes depend on various clinical factors including advanced age, immunocompetence, low BCVA and higher vitritis grade at baseline. New virological factors were found predictive of a poor visual prognosis:high baseline VL and the “slow responder” status. |
| Conflict of interest | No |
Authors 1
| Last name | FITOUSSI |
| Initials of first name(s) | L |
| Department | 75 |
| City | Paris |
| Country | France |
Authors 2
| Last name | TOUHAMI |
| Initials of first name(s) | S |
| Department | 75 |
| City | Paris |
| Country | France |
Authors 3
| Last name | BODAGHI |
| Initials of first name(s) | B |
| Department | 75 |
| City | Paris |
| Country | France |
