Toxoplasmosis in Sydney Australia - a Retrospective cohort
Accept poster if oral is not possible ?
Yes
Purpose
to determine the seveity and clinical course of ocular toxoplasmosis in a major Australian referral center
Methods
Retrospective review of patient files who presented to Sydney Eye Hospital between 2007 and 2017 with clinical features consistent with ocular toxoplasmosis. Visual acuity and relapse rate compared to other studies in ocular toxoplasmosis
Results
48 patients with ocular toxoplasmosis who presented to Sydney Eye Hospital during the period of observation. The median age was 35.5 (IQR 21-50) with 29 (60%) having no previous symptomatic episodes or evidence of chorioretinal scarring. Visual acuity at presentation was 0.51 or 6/19 (SE 0.096) and at follow up 0.31 or 6/9 (SE 0.094). 9 patients experienced a recurrence during the period of observation with time to recurrence 2.2 years (SE 0.45). The relapse rate (1 or more) 0.09/person-year. Location of lesion was predominantly within the vascular arcades (n=44) with macular involvement in 9 patients. Most patients received clindamycin therapy (n=34).
Conclusion
Patients with ocular toxoplasmosis had fewer recurrences compared with other published series and had better visual recovery. The majority of patients received clindamycin and oral prednisolone which was well tolerated with pyrimethazine and sulfadiazine reserved for those with macula involving disease.
Conflict of interest
No
Author 1
Last name
YATES
Initials of first name(s)
W
Department
Save Sight Institute, The University of Sydney
City
Sydney
Country
Australia
Author 2
Last name
Zagora
Initials of first name(s)
S
Department
Save Sight Institute, The University of Sydney
City
Sydney
Country
Australia
Author 3
Last name
McCluskey
Initials of first name(s)
P
Department
Save Sight Institute, The University of Sydney
City
Sydney
Country
Australia
Author 4
Last name
Choong
Initials of first name(s)
F
Department
Department of Infectious Diseases, Prince of Wales
City
Sydney
Country
Australia
Author 5
Last name
Post
Initials of first name(s)
J
Department
Department of Infectious Diseases, Prince of Wales
City
Sydney
Country
Australia
Author 6
Last name
Wakefield
Initials of first name(s)
D
Department
School of Medical Sciences, Sydney Australia
City
Sydney
Country
Australia
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