Killer cell Immunoglobulin-like Receptors and ligands in patients with CMV-Anterior Uveitis
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Purpose
Cytomegalovirus Anterior Uveitis（CMV-AU）manifests in immunocompetent individuals of which the mechanisms are unknown. In this study, we have investigated the role of NK cells in CMV-AU. Important determinants that differentiate human NK responses are the Killer Cell Immunoglobulin-like Receptors (KIR) and their ligands, HLA class I subgroups. Combinations of polymorphisms of KIR and HLA are known to be associated with resistance against virus infection and progression.
Methods
KIR ligands in 118 Chinese Singaporean CMV-AU cases were determined using Next Generation Sequencing (NGS). KIR genotypes were determined using a PCR-SSP method. The data was compared against the profiles of the healthy Chinese Singaporean population.
Results
Among HLA-B Bw4 allele groups (80Ile, 80Thr), the frequency of the 80Ile allele group was significantly increased and the frequency of 80Thr allele group was significantly lower in CMV-AU patients compared to those in healthy controls. No difference was observed in the frequencies of ligands for KIR2DL1/2DL3 and the group A haplotype.
Conclusion
Genetic profiles of KIRs and their ligands in CMV-AU contrast to the KIR/HLA associations reported previously for symptomatic systemic primary CMV infection, implying that the immunological mechanisms against CMV are likely distinct.
Conflict of interest
No
Author 1
Last name
YAWATA
Initials of first name(s)
N
City
Fukuoka
Country
Japan
Author 2
Last name
Siak
Initials of first name(s)
J
Department
Singapore Eye Research Institute, Singapore National Eye Centre, National University of Singapore
City
Singapore
Country
Singapore
Author 3
Last name
Chee
Initials of first name(s)
SP
Department
Singapore Eye Research Institute, Singapore National Eye Centre, National University of Singapore
City
Singapore
Country
Singapore
Author 4
Last name
Kawano
Initials of first name(s)
Y
Department
Fukuoka Dental College
City
Fukuoka
Country
Japan
Author 5
Last name
Yawata
Initials of first name(s)
M
Department
National University of Singapore
City
Singapore
Country
Singapore
Author 6
Last name
Sonoda
Initials of first name(s)
KH
Department
Kyushu University
City
Fukuoka
Country
Japan
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