Predictive Factors of Intraocular Pressure Level Evolution Over Time and Glaucoma Severity in Fuchs
Accept poster if oral is not possible ?
Yes
Purpose
To investigate the clinical and virological predictive factors of intraocular pressure (IOP)evolution and glaucoma severity in Fuchs Heterochromic Iridocyclitis (FHC)
Methods
Consecutive patients with clinical FHC and intraocular synthesis of rubella(RV)-specific antibodies were included.Specific ocular production of RV antibodies was confirmed using the quotient of serum/aqueous humour ratio of RV IgGs (Crv) and control antiviral IgGs (Cctl). Epidemiological, clinical, biological and virological data at referral were collected and correlated with IOP values over time, occurrence and severity of glaucoma
Results
68 eyes of 68 patients were included.Mean age at diagnosis was 40.7±11.1 years.Mean follow-up was 4.3±4.3 years.Mean baseline Crv and Cctl values were 12.34±14.67 and 216.70±98.4.Mean baseline IOP was 17.2±7.2 mmHg [9-40] and 15.6±5.6 [3-30] five years after referral.The predictive factors for pejorative IOP evolution over time and glaucoma severity were male gender (p=0.03) and decreased Crv (p =0.04);and presence of iris nodules (p<0.001) and decreased Cctl (p=0.02) respectively.Diagnostic delay was associated with increased likelihood of undergoing glaucoma surgery (p=0.02)
Conclusion
Time to diagnosis,male gender,presence of iris nodules at baseline and decreased Crv and Cctl ratios were associated with increased likelihood of pejorative IOP evolution. Given the aggressiveness of glaucoma in FHC,these results provide interesting insight on what category of patients should need the closest screening
Conflict of interest
No
Author 1
Last name
TOUHAMI
Initials of first name(s)
S
City
PARIS
Country
France
Author 2
Last name
VANIER
Initials of first name(s)
A
City
NANTES
Country
France
Author 3
Last name
ROSATI
Initials of first name(s)
A
City
ROME
Country
Italy
Author 4
Last name
BOJANOVA
Initials of first name(s)
M
City
PARIS
Country
France
Author 5
Last name
BENRHOMDANE
Initials of first name(s)
B
City
PARIS
Country
France
Author 6
Last name
LEHOANG
Initials of first name(s)
P
City
PARIS
Country
France
Author 7
Last name
ROZENBERG
Initials of first name(s)
F
City
PARIS
Country
France
Author 8
Last name
BODAGHI
Initials of first name(s)
B
City
PARIS
Country
France
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