Usability of blood examinations and imaging examinations in the diagnosis of ocular sarcoidosis
Accept poster if oral is not possible ?
Yes
Purpose
Blood examinations including angiotensin-converting enzyme (ACE), and imaging examinations have been used for diagnosis of sarcoidosis. Recently, soluble interleukin-2 receptor (sIL-2R) was included in Diagnostic Standard and Guideline for Sarcoidosis 2015 (Japan Society of Sarcoidosis and other Granulomatous Disorders). The aim of this study was to evaluate the clinical usefulness of blood examinations including sIL-2R and imaging examinations in the diagnosis of ocular sarcoidosis.
Methods
This retrospective study included 94 cases (male: 27 cases, female: 67 cases) with ocular sarcoidosis who visited Hokkaido University Hospital from 2011 to 2015. 124 cases (male: 56 cases, female: 68 cases) of other uveitis patients were also included as controls. Blood examinations including ACE, KL-6, sIL-2R, serum calcium (s-Ca) and imaging examinations including bilateral hilar lymphadenopathy (BHL) detected by chest X-ray and/or chest computed CT scan were examined.
Results
The sensitivity and the specificity of ACE were 44.0% and 97.9% respectively, and those of KL-6 were 29.5% and 89.2%, those of sIL-2R were 76.5% and 89.6%, those of s-Ca were 12.4% and 95.0%. As for the imaging examinations, the sensitivity and the specificity of BHL with chest X-ray were 29.0% and 97.6% and those of chest computed CT scan were 84.1% and 100%.
Conclusion
It was suggested that sIL-2R and chest computed CT scan were useful in the diagnosis of ocular sarcoidosis.
Conflict of interest
No
Author 1
Last name
SUZUKI
Initials of first name(s)
K
Department
Faculty of Medicine and Graduate School of Medicine, Hokkaido University
City
Sapporo
Country
Japan
Author 2
Last name
Namba
Initials of first name(s)
K
City
Sapporo
Country
Japan
Author 3
Last name
Mizuuchi
Initials of first name(s)
K
City
Sapporo
Country
Japan
Author 4
Last name
Iwata
Initials of first name(s)
D
City
Sapporo
Country
Japan
Author 5
Last name
Ito
Initials of first name(s)
T
City
Sapporo
Country
Japan
Author 6
Last name
Ohno
Initials of first name(s)
S
City
Sapporo
Country
Japan
Author 7
Last name
Kitaichi
Initials of first name(s)
N
City
Sapporo
Country
Japan
Author 8
Last name
Ishida
Initials of first name(s)
S
City
Sapporo
Country
Japan
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