A cross-sectional review of the presenting ocular features of Behçet’s disease in patients from a single centre in the UK
Purpose
Ocular involvement in Behçet’s disease (BD) is common and a component of the International Criteria of Behcet’s Disease (ICBD). It varies with geographic location, however there is limited data from the UK. It is important to understand how BD presents locally to ensure rapid diagnosis and appropriate management. A cross-sectional analysis of all patients registered with the Birmingham Behçet’s Syndrome Centre of Excellence was performed, to determine the prevalence of ocular involvement in this population, and characterise the type and frequency of ocular manifestations.
Methods
A retrospective review of electronic medical records for 541 patients was conducted. Data extracted included sample demographics, ocular manifestations (classified according to ICBD as ‘uveitis’: anterior, intermediate, posterior, pan or unspecified), or ‘other’ (episcleritis, scleritis, optic neuritis, neuroretinitis) and laterality of ocular features.
Results
480 patients had ICBD-confirmed BD, with ocular involvement in 172 (312 eyes). Panuveitis was the most frequently presenting ocular manifestation overall (132 eyes; 42.3%). All ocular presentations were more frequently bilateral than unilateral. Gender differences were observed in presenting features, with panuveitis being the most common in males and anterior uveitis in females (53.4% and 39.4% respectively, p<0.05).
Conclusion
This is the largest cross-sectional review of presenting ocular features of BD from a single centre in the UK to date. This will help clinicians recognise ocular BD, in order to initiate appropriate management early, ultimately improving patient outcomes.
Conflict of interest
No
Authors 1
Last name
SINGH
Initials of first name(s)
A
Department
Birmingham Behçet’s Syndrome National Centre of Excellence
City
Birmingham
Country
United Kingdom
Authors 2
Last name
Sreekantam
Initials of first name(s)
S
Department
Birmingham Behçet’s Syndrome National Centre of Excellence
City
Birmingham
Country
United Kingdom
Authors 3
Last name
Situnayake
Initials of first name(s)
D
Department
Birmingham Behçet’s Syndrome National Centre of Excellence
City
Birmingham
Country
United Kingdom
Authors 4
Last name
Chandratre
Initials of first name(s)
P
Department
Birmingham Behçet’s Syndrome National Centre of Excellence
City
Birmingham
Country
United Kingdom
Authors 5
Last name
Tosounidou
Initials of first name(s)
S
Department
Birmingham Behçet’s Syndrome National Centre of Excellence
City
Birmingham
Country
United Kingdom
Authors 6
Last name
Basker
Initials of first name(s)
S
Department
Birmingham Behçet’s Syndrome National Centre of Excellence
City
Birmingham
Country
United Kingdom
Authors 7
Last name
Murray
Initials of first name(s)
P
Department
Birmingham Behçet’s Syndrome National Centre of Excellence
City
Birmingham
Country
United Kingdom
Authors 8
Last name
Richards
Initials of first name(s)
A
Department
Birmingham Behçet’s Syndrome National Centre of Excellence
City
Birmingham
Country
United Kingdom
Authors 9
Last name
Poveda-Gallego
Initials of first name(s)
A
Department
Birmingham Behçet’s Syndrome National Centre of Excellence
City
Birmingham
Country
United Kingdom
Authors 10
Last name
Higham
Initials of first name(s)
J
Department
Birmingham Behçet’s Syndrome National Centre of Excellence
City
Birmingham
Country
United Kingdom
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