This abstract is assigned to sessions
| Presentation preference | Oral presentation |
| Title | Could different aqueous humor and plasma cytokine profiles help differentiate between ocular sarcoidosis and ocular tuberculosis? |
| Purpose | To assess cytokine levels in aqueous humor (AH) and plasma of three different uveitis entities: definite ocular sarcoidosis (OS), definite OS associated with QuantiFERON-TB Gold test positivity (OS/Q+) and presumed tubercular uveitis (TBU). |
| Methods | All patients underwent complete eye examination, extensive work-up for uveitis, high-resolution chest computerized tomography and, when needed, mediastinal lymph node biopsy. Diagnostic criteria were used to categorize patients as OS, OS/Q+ or TBU. Blood and AH samples were collected before starting any treatment. |
| Results | Thirty-two patients (15 OS, 5 OS/Q+, 12 TBU) were included. The AH concentration of BLC, IFN-γ, IP-10, and TNF-α was significantly higher in OS than in TBU group. A significantly higher concentration of plasma IL-15, IL-2 and TNF-α was found in OS compared to OS/Q+ group. Both AH IL-8 and MIP-3α and plasma IL-10 resulted significantly increased in OS compared to OS/Q+ and TBU groups. |
| Conclusion | The different AH and plasma cytokine profile observed in OS compared to OS/Q+ and TBU may help to differentiate OS from TBU in overlapping clinical phenotypes of granulomatous uveitis (OS/Q+). |
| Conflict of interest | No |
Authors 1
| Last name | DE SIMONE |
| Initials of first name(s) | L |
| Department | Ocular Immunology Unit, AUSL-IRCCS |
| City | Reggio Emilia |
| Country | Italy |
Authors 2
| Last name | BONACINI |
| Initials of first name(s) | M |
| Department | AABI, AUSL-IRCCS |
| City | Reggio Emilia |
| Country | Italy |
Authors 3
| Last name | ALDIGERI |
| Initials of first name(s) | R |
| Department | University of Parma |
| City | Parma |
| Country | Italy |
Authors 4
| Last name | ALESSANDRELLO |
| Initials of first name(s) | F |
| Department | University of Messina |
| City | Messina |
| Country | Italy |
Authors 5
| Last name | MASTROFILIPPO |
| Initials of first name(s) | V |
| Department | Ocular Immunology Unit, AUSL-IRCCS |
| City | Reggio Emilia |
| Country | Italy |
Authors 6
| Last name | GOZZI |
| Initials of first name(s) | F |
| Department | Ocular Immunology Unit, AUSL-IRCCS |
| City | Reggio Emilia |
| Country | Italy |
Authors 7
| Last name | BOLLETTA |
| Initials of first name(s) | E |
| Department | Ocular Immunology Unit, AUSL-IRCCS |
| City | Reggio Emilia |
| Country | Italy |
Authors 8
| Last name | ZERBINI |
| Initials of first name(s) | A |
| Department | AABI, AUSL-IRCCS |
| City | Reggio Emilia |
| Country | Italy |
Authors 9
| Last name | CROCI |
| Initials of first name(s) | S |
| Department | AABI, AUSL-IRCCS |
| City | Reggio Emilia |
| Country | Italy |
Authors 10
| Last name | CIMINO |
| Initials of first name(s) | L |
| Department | Ocular Immunology Unit, AUSL-IRCCS |
| City | Reggio Emilia |
| Country | Italy |
