This abstract is assigned to sessions
| Presentation preference | Poster presentation |
| Title | HLA-B27 AND UVEITIS ASSOCIATED WITH SPONDYLARTHROPATHIES IN A MULTIDISCIPLINARY AUTOIMMUNE DISEASE UNIT: ARE THERE CLINICAL DIFFERENCES BASED ON THE HAPLOTYPE? |
| Purpose | To compare the clinical characteristics of human leucocyte antigen HLA-B27+ uveitis patients with SpA diagnosis (New York criteria, ASAS) receiving systemic therapies with HLA-B27- uveitis patients. |
| Methods | We performed a retrospective and descriptive study by including patients diagnosed with uveitis associated with SpA attending our Multidisciplinary Autoimmune Disease Unit from 2000 to 2020 and compared the clinical profile of patients with uveitis related or not to HLA-B27. |
| Results | We included 73 patients, 78% were HLA-B27+ and 21% were HLA-B27-. HLA-B27- patients were older at diagnosis (43.5±8.9 years vs 39.1±11.6 years, p=0.04). Peripherical articular involvement was more frequent in HLA-B27- patients (44% vs 13%, p=0.01). Uveitis preceded the articular involvement in 75% HLA-B27- patients and in 44% HLA-B27+ (p=0.047). The time since first uveitis flare was longer in the HLA B27+ group: 9.12 years (2.75-12.8) vs 3.56 years (1.34-3.5, p 0.02) in HLA-B27- patients. HLA-B27+ patients showed a higher percentage of bilateral/alternating involvement (61.4% vs 31.2%, p=0.046). Mean recurrence of episodes of uveitis was 3.1 ± 1.78 years in HLA-B27+ patients vs 2.1 ±1.74 years, with no significant difference (p=0.90). |
| Conclusion | Uveitis related with positive HLA-B27 debuted at a younger age, with a higher percentage of bilateral/alternating uveitis involvement and a longer period since first uveitis flare. Uveitis onset preceded articular manifestations more frequently in HLA-B27 negative patients. |
| Conflict of interest | No |
Authors 1
| Last name | SANTOS |
| Initials of first name(s) | C |
| Department | RHEUMATOLOGY |
| City | LEÓN |
| Country | Spain |
Authors 2
| Last name | SENDINO TENORIO |
| Initials of first name(s) | I |
| Department | OPHTALMOLOGY |
| City | LEÓN |
| Country | Spain |
Authors 3
| Last name | ÁLVAREZ CASTRO |
| Initials of first name(s) | C |
| Department | RHEUMATOLOGY |
| City | LEÓN |
| Country | Spain |
Authors 4
| Last name | CORDERO COMA |
| Initials of first name(s) | M |
| Department | OPHTALMOLOGY |
| City | LEÓN |
| Country | Spain |
