The histomorphological state of a rabbit's eye with induced anterior and intermediate non-Infectious uveitis in the absence of its clinical signs, but an increased temperature of the ocular surface
Purpose
To study the histomorphology of rabbit’s eyes with induced non-infectious anterior and intermediate uveitis after disappearance of active anterior uveitis clinical signs, but upon condition of the persisting ocular surface temperature elevation.
Methods
The ocular surface temperature was measured in the projection of the ciliary body pars plana on 17 chinchilla rabbits.
Results
Active anterior uveitis is subjectively resolved after 11 days (SD 2.4). The iris is not thickened, not edematous and not infiltrated with newly arrived cells, which indicates the absence of an active inflammation in iris. But the pars plana and pars plicata of the ciliary body are few edematous and profusely infiltrated by mononuclear cells (mainly various lymphocytes, macrophages and plasma cells). Immune competent cells penetrate into the vitreous in large numbers from the ciliary body. In addition, mononuclear cells spread in vitreous along the retinal inner surface, which indicate an active inflammatory process inside the eye.
Conclusion
In rabbits after active anterior uveitis clinical signs disappearance but upon persisting elevated ocular surface temperature, histomorphologycal signs of active intermediate uveitis are determined and the ciliary body is in the inflammatory exudative-emigration phase.
Conflict of interest
No
Authors 1
Last name
DOROKHOVA
Initials of first name(s)
O
Department
Uveitis department
City
Odesa
Country
Ukraine
Authors 2
Last name
Maltsev
Initials of first name(s)
E
Department
Histomorphologycal lab.
City
Odesa
Country
Ukraine
Authors 3
Last name
Zborovska
Initials of first name(s)
O
Department
Uveitis department
City
Odesa
Country
Ukraine
Authors 4
Last name
Guanjun
Initials of first name(s)
M
Department
Uveitis department
City
Odesa
Country
Ukraine
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