Is “Vitritis” a Prognostic Factor for Uveal Melanoma?
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Yes
Purpose
To investigate the phenomenon of increased vitreous cells noted following five-fraction stereotactic body radiotherapy (SBRT) to uveal melanoma.
Methods
We retrospectively collected data from 14 patients with uveal melanoma who underwent SBRT with a total dose of 50 Gy in five fractions from 2008 to 2017.
Results
Six patients (42.9%) presented with vitreous cells during follow-up with a median onset of 6 months. One patient had vitreous cells 27 months after stereotactic body radiotherapy and the choroidal melanoma progressed in size. Liver metastasis was detected at the same time. Two of the six patients experienced tumor progression which is defined as an increase in tumor volume of more than 25% observed over two examination intervals at least 6 months after radiotherapy while one of the other eight patients without vitreous cells had tumor progression (p = 0.538, Fisher’s exact test). When considering metastasis, one of the six patients with vitreous cells had liver metastasis, none of the other eight patients without vitreous cells developed distant metastasis (p = 0.429, Fisher’s exact test).
Conclusion
No previous article has mentioned the phenomenon of increased vitreous cells following SBRT to uveal melanoma and therefore the significance remains ambiguous. More cases are required to confirm whether or not vitritis is a prognostic factor for uveal melanoma.
Conflict of interest
No
Author 1
Last name
TSUI
Initials of first name(s)
MC
Department
Department of Ophthalmology, National Taiwan University Hospital
City
Taipei
Country
Taiwan
Author 2
Last name
Lin
Initials of first name(s)
CP
Department
Department of Ophthalmology, National Taiwan University Hospital
City
Taipei
Country
Taiwan
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