| Presentation preference | Oral presentation |
| Title | Anterior Segment Optical Coherence Tomography: a non-invasive reliable tool in Evaluating Therapeutic response |
| Accept poster if oral is not possible ? | Yes |
| Purpose | To investigate the utility Anterior Segment Optical Coherence Tomography (AS-OCT) as a tool to evaluate and quantify therapeutic response in the management of active anterior scleritis. |
| Methods | In this prospective observatonal study 18 patients diagnosed with scleritis underwent AS-OCT at presentation one week and one month after starting treatment. The images were analyzed to determine the percentage reduction in thickness over the follow-up
period.
|
| Results | Majority (14/18 77.7%) were nodular scleritis. 4/18 had systemic association (3 had rheumatoid arthritis and 1 positivity for c- ANCA). All patients were started on oral and topical steroids and 6 patients received additional immuno-modulator therapy. The mean scleral thickness prior to treatment was 1.3±0.322mm (range 0.86–1.85 mm which decreased by 14.5% (1.2± 0.298mm) at one week and 30.8% (0.906 ±0.114mm) at one month (p<0.01). Intrascleral edema (linear slit-like hyporeflective spaces) and dilated episcleral vessels also showed decrease at one month. One patient did not show reduction in edema at one month |
| Conclusion | This is the first study to describe AS-OCT as a quantifying tool to assess treatment response in anterior scleritis. Further studies with larger sample size and longer follow-up is necessary to validate these findings |
| Conflict of interest | No |
Author 1
| Last name | MURTHY |
| Initials of first name(s) | S |
| Department | Cornea and Uvea |
| City | Hyderabad |
| Country | India |
Author 2
| Last name | LOOMBA |
| Initials of first name(s) | A |
| Department | Cornea |
| City | Hyderabad |
| Country | India |
Author 3
| Last name | RANJAN |
| Initials of first name(s) | R |
| Department | Cornea |
| City | Hyderabad |
| Country | India |
