| Presentation preference | Oral presentation |
| Title | Objective evaluation of the intraocular inflammation using Swept-Source Optical coherence tomography |
| Accept poster if oral is not possible ? | Yes |
| Purpose | To develop an objective intraocular inflammation composite score. |
| Methods | Healthy controls, patients with inactive uveitis and patients with active uveitis were included. The sample was stratified according to the standard degree of inflammation. SS-OCT images
were processed by different algorithms. We studied 8 items in 3 domains: anterior, intermediate and posterior, which were correlated with SUN, NEI and VAS-10 activity scales. |
| Results | We analyzed 20 healthy eyes and 234 eyes with uveitis. VAS-10 showed a moderate significant correlation with respect to the VA LogMAR (r = 0.415, p <0.0001). After ranking, the chosen items for the final score were: the number of cells in the anterior chamber (NCAC) for the anterior domain, the relative intensity of the vitreous (HD-RIVC) for the intermediate domain and, in the posterior domain: the over-red threshold (ORT) and the central macular thickness (CMT). All selected items showed a high discriminatory power between active and inactive eyes, as well as significant correlation with the corresponding clinical scales and VAS-10. Final composite score (SS-OCT-UAS) was calculated as follows: SS-OCT-UAS=(NCACx0.143)+(HD RIVCx0.294)+(ORTx0.609)+(CMTx0.945). |
| Conclusion | The global intraocular inflammation can be evaluated objectively, continuously, consistently and in a valid manner through the analysis and a combined weighting of different SS-OCT scans. |
| Conflict of interest | No |
Author 1
| Last name | SAINZ DE LA MAZA |
| Initials of first name(s) | M |
| Department | Hospital Clinic |
| City | Barcelona |
| Country | Spain |
Author 2
| Last name | SERRANO |
| Initials of first name(s) | A |
| Department | Hospital Clinic |
| City | Barcelona |
| Country | Spain |
Author 3
| Last name | ESQUINAS |
| Initials of first name(s) | C |
| Department | Hospital Clinic |
| City | Barcelona |
| Country | Spain |
Author 4
| Last name | MONTASELL |
| Initials of first name(s) | A |
| Department | Hospital Clinic |
| City | Barcelona |
| Country | Spain |
Author 5
| Last name | GASCON |
| Initials of first name(s) | J |
| Department | Hospital Clinic |
| City | Barcelona |
| Country | Spain |
Author 6
| Last name | MESQUIDA |
| Initials of first name(s) | M |
| Department | IDIBAPS |
| City | Barcelona |
| Country | Spain |
Author 7
| Last name | ADAN |
| Initials of first name(s) | A |
| Department | Hospital Clinic |
| City | Barcelona |
| Country | Spain |
Author 8
| Last name | LLORENS |
| Initials of first name(s) | V |
| Department | Hospital Clinic |
| City | Barcelona |
| Country | Spain |
