This abstract is assigned to sessions
| Title | The results of anti-TNF-α therapy in pediatric refractory uveitis associated with Behçet’s disease |
| Accept poster if oral is not possible ? | Yes |
| Purpose | To assess the effects of anti-TNF-α therapy in pediatric cases with refractory uveitis of Behçet's disease (BD). |
| Methods | Six children (4 girls, 2 boys) with BD uveitis who were followed between 2010-2017 were enrolled in this study. Their medical records were examined in terms of demographic and clinical data. |
| Results | The mean age of children included in the study was 11.17 (8-16) years. Four children had panuveitis, and two had posterior uveitis. Fundus fluorescein angiography showed retinal vasculitis in all children and macular edema in two children. Initially, conventional immunosuppression therapy was started in all children. During the follow-up visits, treatment success was not achieved and treatment was switched to anti-TNF-α (adalimumab) treatment. After the anti-TNF-α treatment period, uveitic findings of BD were resolved in five children, but were not in one. In all children, no adverse reaction was noted, and anti-TNF-α therapy well tolerated. |
| Conclusion | When conventional immunosuppression therapy failed, treatment of pediatric uveitis of BD with adalimumab may led to clinical signs improvement while providing steroid-sparing effect. However, controlled prospective clinical studies are needed to select adalimumab as first-line therapy in pediatric uveitis of BD. |
| Conflict of interest | No |
Author 1
| Last name | AKYOL |
| Initials of first name(s) | N |
| Department | Karadeniz Technical University, Faculty of Medicine, Department of Ophthalmology |
| City | Trabzon |
| Country | Turkey |
Author 2
| Last name | TURK |
| Initials of first name(s) | A |
| Department | Karadeniz Technical University, Faculty of Medicine, Department of Ophthalmology |
| City | Trabzon |
| Country | Turkey |
Author 3
| Last name | KOSE |
| Initials of first name(s) | B |
| Department | Department of Ophthalmology |
| City | Trabzon |
| Country | Turkey |
Author 4
| Last name | SOGUKSULU TURKCAN |
| Initials of first name(s) | T |
| Department | Department of Ophthalmology |
| City | Trabzon |
| Country | Turkey |
Author 5
| Last name | GURSOY |
| Initials of first name(s) | N |
| Department | Department of Ophthalmology |
| City | Trabzon |
| Country | Turkey |
