Long-term follow-up of combination therapy with rituximab and mycophenolate mofetil in refractory chronic recurrent uveitis associated with Vogt-Koyanagi-Harada disease
Accept poster if oral is not possible ?
No
Purpose
Evaluate the long-term follow-up of combination therapy with rituximab (RTX) and mycophenolate mofetil (MMF) in refractory chronic recurrent uveitis associated with Vogt-Koyanagi-Harada (VKH) disease
Methods
Retrospective case series of patients with refractory chronic recurrent uveitis associated with VKH disease, treated with RTX and MMF. Patients received oral MMF (2g daily) and intravenous RTX at a dose of 1000mg per infusion on days 1 and 15, followed by an infusion at 6 months. RTX infusions were repeated after at least 6 months in cases of uveitis relapse.
The following ocular parameters were monitored: best-corrected visual acuity (BCVA), laser flare photometry (LFP), subfoveal choroidal thickness (SFCT) measurement by enhanced depth imaging optical coherence tomography (EDI-OCT), fluorescein and indocyanine green angiography. Follow-up was conducted over a period of five years
Results
Six patients, 2 males (12 eyes), with a median age of 49.0±16.6 years (range 17-66), were treated with oral MMF and received a mean of 4.5 RTX intravenous infusions. Mean BCVA improved from 20/32 at baseline to 20/25 at follow-up(p=0.02). Mean LFP decreased from 12.6ph/ms (SD=4.2) to 5.9ph/ms (SD=2.5)(p<0.001), while mean SFCT on EDI-OCT decreased from 415.9 µm (SD=217.0) to 276.4µm (SD=124.7)(p=0.01). Patients who required fewer infusions had a higher likelihood of remission. No systemic treatment complications were reported during follow-up
Conclusion
Long-term follow-up of combination therapy with MMF and RTX in chronic recurrent uveitis associated with VKH disease showed a corticosteroid-sparing effect and control of ocular inflammation
Conflict of interest
No
1
Last name
BOLLETTA
Initials of first name(s)
E
Department
Ocular Immunology Unit, AUSL-IRCCS of Reggio Emilia
City
Reggio Emilia
Country
Italy
2
Last name
BELLETTI
Initials of first name(s)
M
Department
Ophthalmology Unit, University of Bologna
City
Bologna
Country
Italy
3
Last name
GIBERTINI
Initials of first name(s)
M
Department
Ophthalmology Unit, University of Modena and Reggio Emilia
City
Modena
Country
Italy
4
Last name
DE SIMONE
Initials of first name(s)
L
Department
Ocular Immunology Unit, AUSL-IRCCS of Reggio Emilia
City
Reggio Emilia
Country
Italy
5
Last name
GOZZI
Initials of first name(s)
F
Department
Ocular Immunology Unit, AUSL-IRCCS of Reggio Emilia
City
Reggio Emilia
Country
Italy
6
Last name
GENTILE
Initials of first name(s)
P
Department
Ocular Immunology Unit, AUSL-IRCCS of Reggio Emilia; University of Modena and Reggio Emilia
City
Reggio Emilia
Country
Italy
7
Last name
CIMINO
Initials of first name(s)
L
Department
Ocular Immunology Unit, AUSL-IRCCS of Reggio Emilia; University of Modena and Reggio Emilia
City
Reggio Emilia
Country
Italy
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