Long-term Outcomes of Intravitreal Fluocinolone Acetonide Implant in Chronic Non-Infectious Uveitis and Uveitic Postoperative Macular Edema
Accept poster if oral is not possible ?
Yes
Purpose
To evaluate the efficacy and safety of the intravitreal fluocinolone acetonide implant in chronic non-infectious uveitis and chronic uveitic postoperative macular edema
Methods
Retrospective review of 18 eyes treated with FAi, with a minimum 12-month follow-up. Primary outcomes included change in best corrected visual acuity (BCVA) and central retinal thickness (CRT). Multiple secondary outcomes were assessed.
Results
Uveitis etiologies included Behçet disease (n=4), polymyalgia rheumatica (n=2), psoriatic arthritis (n=1), multiple sclerosis (n=1), sarcoidosis (n=1), birdshot retinochoroiditis (n=1) and chronic postoperative uveitic ME (n=8). Previous local treatments included IV triamcinolone and dexamethasone implant. Mean BCVA (logMAR) improved from 0.47±0.33 to 0.32±0.29 (p=0.02) at 12 months. At baseline, mild to moderate inflammatory activity on both anterior chamber and vitreous was present in 7 eyes and retinal vasculitis in 7 eyes. All patients with retinal vasculitis showed improvement at 12 months. Mean CRT changed from 330.6±156.7 μm to 278.0±63.1 μm at 12 months (p=0.25). 3 eyes with refractory ME required additional treatment. 2 of the 4 phakic eyes underwent cataract surgery. 2 patients developed ocular hypertension. Regarding eyes with chronic postoperative ME, mean BCVA (logMAR) improved from 0.71±0.33 to 0.39±0.24 (p=0.01) at 12 months. Mean CRT improved from 435.9±55.6 μm at baseline to 302.5±46.8 μm at 12 months (p<0.01). Increased IOP was observed in 3 eyes.
Conclusion
This long-term follow-up study demonstrated that FAi effectively controls inflammation and uveitic macular edema without significant safety concerns.
Conflict of interest
No
1
Last name
FURTADO
Initials of first name(s)
MJ
Department
Unidade Local de Saúde Santo António- Centro Hospitalar Universitário do Porto
City
Porto
Country
Portugal
2
Last name
Vieira
Initials of first name(s)
R
Department
Unidade Local de Saúde Santo António- Centro Hospitalar Universitário do Porto
City
Porto
Country
Portugal
3
Last name
Pires
Initials of first name(s)
D
Department
Unidade Local de Saúde Santo António- Centro Hospitalar Universitário do Porto
City
Porto
Country
Portugal
4
Last name
Vieira
Initials of first name(s)
B
Department
Unidade Local de Saúde Santo António- Centro Hospitalar Universitário do Porto
City
Porto
Country
Portugal
5
Last name
Pessoa
Initials of first name(s)
B
Department
Unidade Local de Saúde Santo António- Centro Hospitalar Universitário do Porto
City
Porto
Country
Portugal
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