SAFETY OF INTRAVENOUS METHYLPREDNISOLONE IN REFRACTORY AND SEVERE PEDIATRIC UVEITIS
Purpose
To evaluate the safety of intravenous high-dose pulse methylprednisolone succinate (IVHDM) in the management of severe or refractory non-infectious pediatric uveitis.
Methods
We reviewed all uveitis patients who were ≤16 years of age and who received IVHDM with a dose of ≥500 mg per day (1–3 days a month) for at least 3 months during their management at a tertiary care eye hospital.
Results
Twenty pediatric patients with severe or refractory uveitis who received IVHDM were identified. Six patients were excluded, the remaining 14 patients received IVHDM for at least 4 months. Age (mean±SD) was 11.9±2.4 years and 50% were female. Duration of treatment was 14.2±7.5 months. Thirteen patients received IVHDM in combination with other immunomodulatory therapy. Except for two outliers, IVHDM was given at a dose of 8–25 mg/kg per infusion. Three major adverse events (AEs) occurred in two patients and the number of AEs (major and minor) strongly correlated with duration of treatment (p=0.004) and moderately correlated with the cumulative dose/weight (p=0.051).
Conclusion
IVHDM may be a valid therapeutic option for aggressive/refractory pediatric uveitis. The reported AEs in this series can also be attributed to the concurrent IMT or the underlying disease itself.
Conflict of interest
No
Authors 1
Last name
SENDINO TENORIO
Initials of first name(s)
I
Department
Complejo Asistencial Universitario de León
City
León
Country
Spain
Authors 2
Last name
Ghoraba
Initials of first name(s)
H
Department
pencer Center for Vision Research, Byers Eye Institute, Stanford University
City
Palo Alto
Country
United States
Authors 3
Last name
Matsumiya
Initials of first name(s)
W
Department
pencer Center for Vision Research, Byers Eye Institute, Stanford University
City
Palo Alto
Country
United States
Authors 4
Last name
Khojasteh
Initials of first name(s)
H
Department
pencer Center for Vision Research, Byers Eye Institute, Stanford University
City
Palo Alto
Country
United States
Authors 5
Last name
Akhavanrezayat
Initials of first name(s)
A
Department
pencer Center for Vision Research, Byers Eye Institute, Stanford University
City
Palo Alto
Country
United States
Authors 6
Last name
Karaca
Initials of first name(s)
I
Department
pencer Center for Vision Research, Byers Eye Institute, Stanford University
City
Palo Alto
Country
United States
Authors 7
Last name
Or
Initials of first name(s)
C
Department
pencer Center for Vision Research, Byers Eye Institute, Stanford University
City
Palo Alto
Country
United States
Authors 8
Last name
Yavari
Initials of first name(s)
N
Department
pencer Center for Vision Research, Byers Eye Institute, Stanford University
City
Palo Alto
Country
United States
Authors 9
Last name
Do
Initials of first name(s)
D
Department
pencer Center for Vision Research, Byers Eye Institute, Stanford University
City
Palo Alto
Country
United States
Authors 10
Last name
Dong Nguyen
Initials of first name(s)
Q
Department
pencer Center for Vision Research, Byers Eye Institute, Stanford University
City
Palo Alto
Country
United States
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