| Presentation preference | Oral presentation |
| Title | Association between incident uveitis and sight-threatening ocular comorbidities; population-based insights from UK |
| Purpose | Uveitis is an important direct and indirect cause of vision loss. We explored strength of association with sight-threatening ocular comorbidities. |
| Methods | Matched case-control and matched cohort study (1:4 on age, sex, region and townsend deprivation index) using primary care record data from 11 million NHS patients |
| Results | Between 1995 and 2018 we identified 24,895 incident uveitis patients (901 onset age≤17 y), and matched 99,579 controls. 67.1% had anterior uveitis, 28.6% unspecified uveitis, 3.7% posterior, 0.5% pan, and 0.2% intermediate uveitis. An infectious or immune-mediated inflammatory disease (I-IMID) was diagnosed prior to incident uveitis in 28.4% (17.3% controls), and subsequent to incident uveitis in 13.9% (4.9% controls). Adjusting for age, sex, ethnicity, TDI, smoking, BMI, country, diabetes and any I-IMID diagnosis, incident uveitis cases were significantly more likely than controls to have prior diagnosis of macular oedema (OR 6.4), band keratopathy (OR 5.3), cataract (OR 4.9), glaucoma (OR 3.6), ocular hypertension (OR 2.9), retinal detachment (OR 5.4), optic neuritis (OR 2.7) or scleritis (OR 9.8); and were more likely to have had cataract extraction (OR 5.5)(all p<0.001). Adjusting for the same variables, incident uveitis cases were significantly more likely to develop subsequent macular oedema (HR 11.8), band keratopathy (HR 18.1), cataract (HR 2.1), glaucoma (HR 3.6), ocular hypertension (HR 3.1), retinal detachment (HR 7.2), optic neuritis (HR 6.2) or scleritis (HR 39.9); and were more likely need cataract extraction (HR 2.3)(all p<0.001). |
| Conclusion | Uveitis is strongly and independently associated with other sight-threatening ocular comorbidities |
| Conflict of interest | No |
| Last name | BRAITHWAITE |
| Initials of first name(s) | T |
| Department | The Medical Eye Unit, Guy's & St Thomas' NHS Foundation Trust |
| City | London |
| Country | United Kingdom |
| Last name | Subramanian |
| Initials of first name(s) | A |
| Department | The Institute of Applied Health Research, University of Birmingham |
| City | Birmingham |
| Country | United Kingdom |
| Last name | Kempen |
| Initials of first name(s) | JH |
| Department | Department of Ophthalmology and Schepens Eye Research Institute, Massachusetts Eye and Ear and Harva |
| City | Boston |
| Country | United States |
| Last name | Adderley |
| Initials of first name(s) | NJ |
| Department | The Institute of Applied Health Research, University of Birmingham |
| City | Birmingham |
| Country | United Kingdom |
| Last name | Galloway |
| Initials of first name(s) | J |
| Department | Centre for Rheumatic Diseases, School of Immunology and Microbial Sciences, KCL |
| City | London |
| Country | United Kingdom |
| Last name | Solebo |
| Initials of first name(s) | AL |
| Department | UCL Great Ormond Street Institute of Child Health, University College London |
| City | London |
| Country | United Kingdom |
| Last name | Cope |
| Initials of first name(s) | AP |
| Department | Centre for Rheumatic Diseases, School of Immunology and Microbial Sciences, KCL |
| City | London |
| Country | United Kingdom |
| Last name | Dick |
| Initials of first name(s) | AD |
| Department | Institute of Ophthalmology, University College London |
| City | London |
| Country | United Kingdom |
| Last name | Nirantharakumar |
| Initials of first name(s) | K |
| Department | The Institute of Applied Health Research, University of Birmingham |
| City | London |
| Country | United Kingdom |
| Last name | Denniston |
| Initials of first name(s) | AK |
| Department | University Hospitals Birmingham NHS Foundation Trust |
| City | Birmingham |
| Country | United Kingdom |