A four-year trend in full-field electroretinogram (ff-ERG) in patients with Vogt-Koyanagi-Harada disease
Purpose
To retrospectively evaluate a four-year trend in ff-ERG and its association with clinical aspects in patients with Vogt-Koyanagi-Harada disease VKHD) followed up since acute onset.
Methods
Twenty one consecutive acute VKHD patients (42 eyes), attended at a tertiary center from June 2011 to January 2017, and followed up for at least 48 months, with systematic multimodal and ff-ERG evaluations, were included. Scotopic and photopic ff-ERG parameters at month(M)1, M6, M12 and M48 were analyzed. At M48, eyes were grouped according to the number of abnormal parameters (below the 5th percentile of normal controls): group 1 (none), group 2 (1 to 3) and group 3 (4 to 7). Correlation between ff-ERG results at M48 with clinical and treatment data was pursued. Generalized estimated equations were used for binary ocular data. Interaction P-value, using multivariable models, was used for significant subgroup differences.
Results
Subgroups 4-point curves had different behavior for maximum scotopic b amplitude (p=0.005), photopic b amplitude (p=0.024) and flicker (p=0.003). Concerning the other parameters, except for photopic a amplitude, the curves between the groups were parallel (p<0.001). Interval to treatment was shorter in group 1 than in group 2. Fluorescein and indocyanine green angiographies total score at baseline were lower in group 1 than groups 2 and 3. All patients from group 3 had additional immunosuppressive therapy (p<0.001) and were the group with less anterior uveitis relapses (p<0.001).
Conclusion
Delay in treatment start and more intense inflammation at baseline seemed to be the main factors to define visual function measured by ff-ERG at a long-term follow-up in VKHD.
Conflict of interest
No
Authors 1
Last name
YAMAMOTO
Initials of first name(s)
JH
Department
Ophthalmology, LIM 33, Faculdade de Medicina, Universidade de Sao Paulo
City
Sao Paulo
Country
Brazil
Authors 2
Last name
Souto
Initials of first name(s)
FMS
Department
Ophthalmology, Faculdade de Medicina, Universidade de Sao Paulo
City
Sao Paulo
Country
Brazil
Authors 3
Last name
Missaka
Initials of first name(s)
RFBG
Department
Ophthalmology, Faculdade de Medicina, Universidade de Sao Paulo
City
Sao Paulo
Country
Brazil
Authors 4
Last name
Lavezzo
Initials of first name(s)
MM
Department
Ophthalmology, Faculdade de Medicina, Universidade de Sao Paulo
City
Sao Paulo
Country
Brazil
Authors 5
Last name
Nobrega
Initials of first name(s)
PFC
Department
Ophthalmology, Faculdade de Medicina, Universidade de Sao Paulo
City
Sao Paulo
Country
Brazil
Authors 6
Last name
Sakata
Initials of first name(s)
VM
Department
Ophthalmology, Universidade Federal do Parana
City
Parana
Country
Brazil
Authors 7
Last name
Oyamada
Initials of first name(s)
MK
Department
Ophthalmology, Faculdade de Medicina, Universidade de Sao Paulo
City
Sao Paulo
Country
Brazil
Authors 8
Last name
Hirata
Initials of first name(s)
CE
Department
Ophthalmology, Faculdade de Medicina, Universidade de Sao Paulo
City
Sao Paulo
Country
Brazil
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