This abstract is assigned to sessions
| Presentation preference | Poster presentation |
| Title | Persistent placoid maculopathy associated with cerebral vasculitis |
| Purpose | To describe a case report of persistent placoid maculopathy (PPM) associated with cerebral vasculitis |
| Methods | Patient managed at a tertiary eye care center since december 2020 was included |
| Results | A 46-year-old patient presented a severe bilateral visual impairment and bilateral central scotoma, occurring after 7-day febrile episode and headache, in Israel. Visual acuity was 20/200 in the right eye and 20/63 in the left eye. There is a first diagnosis of acute posterior multifocal placoid pigment epitheliopathy (APMPPE). He was treated with intravenous pulses of methylprednisolone followed by oral corticosteroids. Two weeks later, he presented a sensory disorder of the left hemisphere and a dysexecutive syndrome, due to a cerebral vasculitis. He was treated with intravenous cyclophosphamide. Despite immunosuppressive treatment, he had a cerebral progression and was addressed to a tertiary eye care center in Paris. Multimodal imaging reveals a bilateral and symmetric PPM. All extensive etiological investigation were negative, even brain biopsy, but quantiFERON-TB Gold was positive and confirmed a latent tuberculosis infection. Patient received only antitubercular treatment and oral corticosteroids. He had no recurrence of cerebral vasculitis nor posterior uveitis of PPM. |
| Conclusion | Persistent placoid maculopathy is a rare condition, and only one case reported an association with a cerebral vasculitis whereas it has been more frequently found in APMPPE. Etiological diagnosis is difficult, and latent tuberculosis should be investigated before immunosuppressive therapy. |
| Conflict of interest | No |
Authors 1
| Last name | TOUTÉE |
| Initials of first name(s) | A |
| Department | Ophthalmology |
| City | Paris |
| Country | France |
Authors 2
| Last name | HOURY |
| Initials of first name(s) | R |
| Department | Ophthalmology |
| City | Paris |
| Country | France |
Authors 3
| Last name | SAADOUN |
| Initials of first name(s) | D |
| Department | Internist |
| City | Paris |
| Country | France |
Authors 4
| Last name | PAQUES |
| Initials of first name(s) | M |
| Department | Ophthalmology |
| City | Paris |
| Country | France |
Authors 5
| Last name | BODAGHI |
| Initials of first name(s) | B |
| Department | Ophthalmology |
| City | Paris |
| Country | France |
