Idiopathic MFC and PIC: an evaluation in pregnancy
Purpose
To evaluate the clinical course of idiopathic multifocal choroiditis (MFC) and punctate inner choroidopathy (PIC) and the efficacy and safety of treatment options during pregnancy.
Methods
Patients with MFC or PIC and a pregnancy in 2011–2019 were enrolled. For the most recent pregnancy, data on best corrected visual acuity (BCVA) before and after pregnancy, relapse rate in pregnancy and postpartum period and maternal and neonatal outcomes were collected. Treatment regimens consisted of a wait-and-see regime and an immunosuppressive treatment with systemic corticosteroids and/or azathioprine, both combined with intravitreal anti-VEGF injections when indicated.
Results
Sixteen women (26 affected eyes) were included. Median Snellen BCVA was 20/19 before pregnancy and 20/18 after delivery. In nine pregnancies an immunosuppressive treatment regime was carried out. Fourteen intravitreal anti-VEGF injections were given in six pregnancies. The relapse rate during pregnancy was 44% and in the postpartum period 31%. Maternal and fetal complications occurred in 31% and 13% of the pregnancies, respectively. Fifteen healthy children were born and one pregnancy ended in a stillbirth in a patient with a complicated obstetrical history. One patient treated with azathioprine developed intrahepatic cholestasis of pregnancy (ICP).
Conclusion
Among pregnant women with MFC and PIC, BCVA remained stable despite a relapse rate of 44% in pregnancy. No major maternal and fetal complications occurred in treated pregnant patients, though one patient developed ICP.
Conflict of interest
No
Authors 1
Last name
OSSEWAARDE-VAN NOREL
Initials of first name(s)
J
Department
University Medical Center Utrecht
City
Utrecht
Country
Netherlands
Authors 2
Last name
de Groot
Initials of first name(s)
EL
Department
UMCU
City
Utrecht
Country
Netherlands
Authors 3
Last name
Bloemenkamp
Initials of first name(s)
KWM
Department
UMCU
City
Utrecht
Country
Netherlands
Authors 4
Last name
van Huet
Initials of first name(s)
RAC
Department
Radboud UMC
City
Nijmegen
Country
Netherlands
Authors 5
Last name
de Boer
Initials of first name(s)
JH
Department
UMCU
City
Utrecht
Country
Netherlands
This website uses cookies to ensure you get the best experience on our website.
Learn more