The paradigm shift of the treatment for Paediatric uveitis - the use of disease modifying biologics
Accept poster if oral is not possible ?
Yes
Purpose
Paediatric uveitis may have a debilitating impact upon children due to treatment failure and disease progression resulting in Paediatric Cataract and Glaucoma. Biologic agents are a relatively new treatment with promising outcomes. Traditionally corticosteroids (both topical and oral) and immunosuppressive agents such as methotrexate were used for the treatment of uveitis.
Methods
Retrospective, chart review demographic data, treatment efficacy, failure and safety over an 8-year period of 27 paediatric uveitis patients (49 eyes) at a quaternary referral eye hospital in Sydney, Australia treated with biologic agents followed up to 1 year were included.
Results
Of the 27 patients (49 eyes), 43% had increased IOP, 40% Cataract and 25% some form of glaucomatous optic neuropathy at presentation. Biologic therapy over 1 year was effective with prednisolone reduced to <5mg/day in 5 of 6 patients (83%), systemic steroid-sparing agents was reduced to ≤ 1 in 2 of 4 patients (50%), and cessation of topical steroid achieved in 12 of 41 of eyes (29%). Cessation of topical steroids was achieved in 7/45 eyes (16% (95% CI, 7.7-28.8)) at 6 weeks of follow-up, 10/43 eyes (23% (95% CI, 13.2-37.7)) at 6 months of follow-up, and 12/41 eyes (29% (95% CI, 17.6-44.5)) at 12 months of follow-up.
Conclusion
Biologic therapy was demonstrated to be effective and safe in paediatric uveitis in the real-world setting. It resulted in reduction of corticosteroid burden, and number of steroid-sparing agents.
Conflict of interest
No
Author 1
Last name
ZAGORA
Initials of first name(s)
SL
Department
Discipline of Ophthalmology, University of Sydney
City
Sydney
Country
Australia
Author 2
Last name
Oh
Initials of first name(s)
L
Department
Discipline of Ophthalmology, University of Sydney
City
Sydney
Country
Australia
Author 3
Last name
McCluskey
Initials of first name(s)
PM
Department
Discipline of Ophthalmology, University of Sydney
City
Sydney
Country
Australia
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