The results of anti-TNF-α therapy in pediatric refractory uveitis associated with Behçet’s disease
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Yes
Purpose
To assess the effects of anti-TNF-α therapy in pediatric cases with refractory uveitis of Behçet's disease (BD).
Methods
Six children (4 girls, 2 boys) with BD uveitis who were followed between 2010-2017 were enrolled in this study. Their medical records were examined in terms of demographic and clinical data.
Results
The mean age of children included in the study was 11.17 (8-16) years. Four children had panuveitis, and two had posterior uveitis. Fundus fluorescein angiography showed retinal vasculitis in all children and macular edema in two children. Initially, conventional immunosuppression therapy was started in all children. During the follow-up visits, treatment success was not achieved and treatment was switched to anti-TNF-α (adalimumab) treatment. After the anti-TNF-α treatment period, uveitic findings of BD were resolved in five children, but were not in one. In all children, no adverse reaction was noted, and anti-TNF-α therapy well tolerated.
Conclusion
When conventional immunosuppression therapy failed, treatment of pediatric uveitis of BD with adalimumab may led to clinical signs improvement while providing steroid-sparing effect. However, controlled prospective clinical studies are needed to select adalimumab as first-line therapy in pediatric uveitis of BD.
Conflict of interest
No
Author 1
Last name
AKYOL
Initials of first name(s)
N
Department
Karadeniz Technical University, Faculty of Medicine, Department of Ophthalmology
City
Trabzon
Country
Turkey
Author 2
Last name
TURK
Initials of first name(s)
A
Department
Karadeniz Technical University, Faculty of Medicine, Department of Ophthalmology
City
Trabzon
Country
Turkey
Author 3
Last name
KOSE
Initials of first name(s)
B
Department
Department of Ophthalmology
City
Trabzon
Country
Turkey
Author 4
Last name
SOGUKSULU TURKCAN
Initials of first name(s)
T
Department
Department of Ophthalmology
City
Trabzon
Country
Turkey
Author 5
Last name
GURSOY
Initials of first name(s)
N
Department
Department of Ophthalmology
City
Trabzon
Country
Turkey
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