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Title	Rapid course of CNV and response to treatment in a case of PIC
Accept poster if oral is not possible ?	Yes

Purpose	To report the rapid course of choroidal neovascularization(CNV) and its response to intravitreal injection(IVI) of aflibercept in a case of punctate inner choroidopathy(PIC).
Methods	Case report
Results	A 22-year-old woman presented with blurred vision and central scotoma in the right eye(RE) for 1 year and left eye(LE) in recent 2 weeks. Best corrected visual acuity was 0.3(RE, -6.25 -1.00 X 170) and 0.5(LE, -6.25 -1.50 X 180). Ocular examination showed bilateral yellowish white chorioretinal lesions at posterior pole without ocular inflammation. There was more pigmentation in RE than LE. SD-OCT showed retinal pigment epithelium(RPE) disruption and hyperreflective material in both eyes as well as RPE detachment in RE. OCT angiography(OCTA) detected a large CNV at right macula, while a suspicious tiny one at left macula. Fundus fluorescein angiography(FAG) showed staining of the above lesions and leaking CNV at late phase RE>LE. 1 week after FAG, her vision dropped with obvious CNV in LE. IVI aflibercept(2mg/0.05 ml) of LE combining oral steroid was given. 3 days later, the CNV size decreased a lot on OCTA with vision improved to 0.8. IVI aflibercept of RE was given with slow tapering of oral steroid and she kept follow-up by slit lamp exam and OCTA in our clinic.
Conclusion	Like other uveitis related CNV, the CNV in PIC is sometimes difficult to be detected and measured in FAG. OCTA has advantages of three-dimensional view of retinal and choroidal vessels without interference by dye leakage or staining in FAG. We reported a case of PIC, which had distinct features of CNV progression and response to treatment demonstrated by OCTA.
Conflict of interest	No

Author 1

Last name	WANG
Initials of first name(s)	TW
Department	Department of Ophthalmology, KSVGH
City	Kaohsiung
Country	Taiwan

Author 2

Last name	Sheu
Initials of first name(s)	SJ
Department	Department of Ophthalmology, KSVGH
City	Kaohsiung
Country	Taiwan