This abstract is assigned to sessions
| Title | Localized amyloidosis involving lacrimal gland and conjunctiva in Sjogren syndrome |
| Accept poster if oral is not possible ? | Yes |
| Purpose | To report localized amyloidosis involving the lacrimal gland and conjunctiva in a patient with Sjogren syndrome (SS).
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| Methods | A 56-year-old female had SS from twenty years ago. The patient suffered from upper eyelid swelling in her left eye for five months. She was referred for managements of a mass OS observed in a nearby clinic in October 2018. Her visual acuity was 20/20 OS with a normal intraocular pressure. Superficial punctate keratopathy (SPK) was seen at the lower part in both eyes, and Schirmer’s test was positive (R=2mm, L=3mm). We conducted an insertion of lacrimal plug. Orbital computed tomography (CT) showed a mild enlargement of the left lacrimal gland. We conducted an excisional biopsy of the lacrimal gland mass after informed consent was obtained. |
| Results | Histopathologic examination showed the deposition of amorphous eosinophilic substance not only in the lacrimal gland but also beneath the conjunctival epithelium that demonstrated birefringence of apple-green color on Direct Fast Scarlet (DFS) staining, suggestive of amyloid under a polarizing microscope. The patient referred to the department for additional evaluation for amyloidosis, and was diagnosed with localized secondary amyloidosis of the lacrimal gland.
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| Conclusion | Physicians should be aware of the existence of amyloidosis in a case of upper eyelid swelling with SS. |
| Conflict of interest | No |
Author 1
| Last name | ITO |
| Initials of first name(s) | T |
| Department | Ophthalmology, Hokkaido University |
| City | Sapporo |
| Country | Japan |
Author 2
| Last name | Kase |
| Initials of first name(s) | S |
| Department | Ophthalmology, Hokkaido University |
| City | Sapporo |
| Country | Japan |
Author 3
| Last name | Ishijima |
| Initials of first name(s) | K |
| Department | Ophthalmology, Hokkaido University |
| City | Sapporo |
| Country | Japan |
Author 4
| Last name | Suimon |
| Initials of first name(s) | Y |
| Department | Ophthalmology, Hokkaido University |
| City | Sapporo |
| Country | Japan |
Author 5
| Last name | Takakuwa |
| Initials of first name(s) | E |
| Department | Pathology, Hokkaido University |
| City | Sapporo |
| Country | Japan |
Author 6
| Last name | Ishida |
| Initials of first name(s) | S |
| Department | Ophthalmology, Hokkaido University |
| City | Sapporo |
| Country | Japan |
