This abstract is assigned to sessions
| Title | Association study of KIR alleles with Behçet's disease in a Japanese population |
| Accept poster if oral is not possible ? | Yes |
| Purpose | Behçet's disease (BD) is a chronic systemic inflammatory disorder involving recurrent ocular symptoms, oral and genital ulcers, and skin lesions. BD is strongly associated with the HLA class I alleles, HLA-B*51 and -A*26. Killer cell immunoglobulin-like receptors (KIRs) are the key receptors for human NK cells that bind specific HLA class I ligands. KIR alleles play activating or inhibitory roles in NK cells and are reportedly associated with several immune-related diseases; however, the association between KIR alleles and BD remains unclear. Here we assessed whether KIR alleles were associated with BD in a Japanese population. |
| Methods | 608 Japanese BD patients and 1587 Japanese controls were recruited. We imputed KIR and HLA alleles from genome-wide SNP data using KIR*IMP and SNP2HLA, respectively. |
| Results | The inhibitory KIR receptor 2DL2 and activating receptor 2DS2 were associated with the increased risk of BD (corrected P (Pc)<0.05: OR=1.62 and 1.60, respectively). Two activating receptors, 2DS4 and 3DS1, were associated with the decreased risk (Pc<0.05: OR=0.48 and 0.72, respectively). Additionally, three inhibitory KIR-HLA pairs, 2DL1-C2, 2DL2-C1 and 3DL1-Bw4I80, and one activating pair, 2DS2-C1, were associated with the increased risk (Pc<0.05: OR=1.59, 1.59, 2.22 and 1.56, respectively), whereas two inhibitory pairs, 3DL1-Bw4T80 and 3DL2-A3/A11, were associated with the decreased risk (Pc<0.05: OR=0.63 and 0.56, respectively). |
| Conclusion | Our results suggest that some KIR alleles and KIR-HLA combinations contribute to the BD risk. To confirm our findings, future validation studies are needed. |
| Conflict of interest | No |
Author 1
| Last name | MEGURO |
| Initials of first name(s) | A |
| City | Yokohama |
| Country | Japan |
Author 2
| Last name | TAKEUCHI |
| Initials of first name(s) | M |
| City | Yokohama |
| Country | Japan |
Author 3
| Last name | YAMANE |
| Initials of first name(s) | T |
| City | Yokohama |
| Country | Japan |
Author 4
| Last name | HORITA |
| Initials of first name(s) | N |
| City | Maryland |
| Country | United States |
Author 5
| Last name | MIZUKI |
| Initials of first name(s) | N |
| City | Yokohama |
| Country | Japan |
