To present the anatomic and functional results of oral treatment for toxoplasmic retinochoroiditis.
Methods
This is a case series carried out by detailed chart review.
Results
Case 1: A healthy 18 year old man presented with progressive vision loss of right eye for a week. Fundoscopy revealed a creamy patch with dome-shaped elevation over the macula. Optical coherence tomography (OCT) showed subretinal fluid over the macula. Panuveitis survey revealed positive toxoplasma IgG and negative IgM. After 2 months' treatment with CDC formula (pyrimethamine 100mg loading and 25mg twice a day, clindamycin 300mg every 6 hours, and prednisolone added one week later), subretinal fluid resolved, leaving a scar at the fovea. Corrected visual acuity was 0.1
Case 2: A healthy 20-year-old woman had progressive vision loss of right eye for 2 weeks. Fundoscopy revealed a large creamy patch over macula with vitreous condensation. OCT showed hyperreflective retina with disrupted photorecepter layer at macula. Toxoplasma IgG was positive and IgM negative. After 2 months' treatment with CDC formula, a scar remained at the macula. Corrected visual acuity was 0.1.
Case 3: A healthy 49-year-old man had blurred vision of left eye for a month. There were creamy patches over the superior arcade, and macular pucker with edema. Toxoplasma IgG and IgM were positive. A month after starting CDC formula, the creamy patches resolved, but progression of macular edema was noted. Rechecked toxoplasma IgM at 2 months was negative. Corrected visual acuity was 0.2.
Conclusion
Ocular toxoplasmosis involving macula should be early recognized and treated aggressively.
Conflict of interest
No
Author 1
Last name
KUO
Initials of first name(s)
SY
Department
Kaohsiung Veterans General Hospital
City
Kaohsiung
Country
Taiwan
Author 2
Last name
CHEN
Initials of first name(s)
SC
Department
Kaohsiung Veterans General Hospital
City
Kaohsiung
Country
Taiwan
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