Retreatment Criteria in Fluocinolone Acetonide implant treated Non-Infectious Uveitis (NIU)
Accept poster if oral is not possible ?
Yes
Purpose
Fluocinolone acetonide implant (FAc, 0.2mg/day, ILUVIEN®) is licenced in the UK for the prevention of uveitis recurrence. We report the results in the largest single-centre cohort of eyes with NIU treated with FAc, allowing real-world evaluation of safety and efficacy focusing on retreatment criteria.
Methods
Patients treated with FAc for NIU between November 2019 and March 2021 were identified using a standardised audit tool. Parameters; demographics, type & severity of uveitis, best corrected visual acuity (BCVA, LogMAR), intraocular pressure (IOP, mmHg) central macula thickness (CMT, mm) and number and type of adjunctive treatments.
Results
161 injected eyes had full 3 year plus follow-up available for analysis. In 86% Uveitic macula edema (UME) was treatment indication.
At baseline 98 eyes were pseudophakic, with 56 (89%) becaming pseudophakic during follow-up. Mean IOP remained 12-13mmHg
with 9 eyes (5.6%) having filtering surgery to control IOP.
After 3 years, 90 eyes (56%) had a sustained decrease in CMT and needed no further intervention. 19 eyes (12%) needed early and ongoing adjunctive dexamethasone (Ozurdex®) injections. 40 eyes (25%) had a partial response.
Conclusion
ILUVIEN® FAc implants have proven to be safe and efficacious over a 3 year period. This is the largest single-centre cohort of NIU patients treated with FAc.
25% of the eyes treated had a partial response that included those with waning effect and retreatment between years 2 to 3.
Using such measures of qualified success the overall rate of efficacy was 81%.
The primary indication to treat is UME, IOP rises were controlled. Of note 89% of phakic patients had cataract surgery within 3 years.
Conflict of interest
Yes
Details of conflicting interests
Alimera Sciences - Consultant
1
Last name
TUCKER
Initials of first name(s)
W
Department
Moorfields Eye Hospital NHS Foundation Trust
City
London
Country
United Kingdom
2
Last name
PAVESIO
Initials of first name(s)
C
Department
Moorfields Eye Hospital NHS Foundation Trust
City
London
Country
United Kingdom
3
Last name
TESTI
Initials of first name(s)
I
Department
Moorfields Eye Hospital NHS Foundation Trust
City
London
Country
United Kingdom
4
Last name
REES
Initials of first name(s)
A
Department
Moorfields Eye Hospital NHS Foundation Trust
City
London
Country
United Kingdom
5
Last name
WESTCOTT
Initials of first name(s)
M
Department
Moorfields Eye Hospital NHS Foundation Trust
City
London
Country
United Kingdom
6
Last name
PETRUSHKIN
Initials of first name(s)
H
Department
Moorfields Eye Hospital NHS Foundation Trust
City
London
Country
United Kingdom
7
Last name
CHU
Initials of first name(s)
C
Department
Moorfields Eye Hospital NHS Foundation Trust
City
London
Country
United Kingdom
8
Last name
GURBAXANI
Initials of first name(s)
A
Department
Moorfields Eye Hospital NHS Foundation Trust
City
London
Country
United Kingdom
9
Last name
ADDISON
Initials of first name(s)
P
Department
Moorfields Eye Hospital NHS Foundation Trust
City
London
Country
United Kingdom
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