Intravitreal steroid implants in uveitic macular oedema: real-world efficacy and safety
Accept poster if oral is not possible ?
Yes
Purpose
Intravitreal steroid implants are established treatments for macular oedema (CME) in non-infectious uveitis (NIU). However, real-world data on the efficacy and safety of dexamethasone (DEX) and fluocinolone acetonide (FAc) implants are limited including studies investigating both agents in same patients. This study investigated the efficacy and safety of these implants.
Methods
This retrospective real-world study included 84 eyes of 70 patients with NIU, who were either treated solely with DEX- (n=49) or FAc-implants (n=14), or with a consecutive combination of both (n=21). Best corrected visual acuity (BCVA), intraocular pressure (IOP), central macular thickness (CMT) at baseline and follow-up visits were investigated (up to 36 months).
Results
Four weeks after the initial intravitreal administration of DEX- and FAc-implants, a BCVA improvement of 0.2 logMAR and 0.22 logMAR, respectively, and a CMT reduction of 73µm and 57µm, respectively, was observed. Recurrence of CME was observed after 173 days (DEX-) and 1052 days (FAc-implants). Among eyes treated exclusively with DEX, a single injection was sufficient in 66%, 34% required additional injections (average: after 182 days). For FAc-treated eyes (n=14), 79% achieved CME resolution with a single injection, 21% eyes required a second FAc (average: after 1052 days). 21 eyes received both DEX and FAc; 10 eyes received FAc after a single DEX injection, while 11 eyes received more than two DEX previously. Adverse events included elevated IOP (n=12), implant dislocation (n=5), and retinal detachment (n=1).
Conclusion
This study supports the efficacy and safety of DEX- and FAc-implants in treating CME in NIU; a combination regimen may leverage the strengths of each.
Conflict of interest
No
1
Last name
BIRTEL
Initials of first name(s)
J
Department
Department of Ophthalmology, University Medical Center Hamburg-Eppendorf
City
Hamburg
Country
Germany
2
Last name
Özen
Initials of first name(s)
A
Department
Department of Ophthalmology, University Medical Center Hamburg-Eppendorf
City
Hamburg
Country
Germany
3
Last name
Grohmann
Initials of first name(s)
C
Department
Department of Ophthalmology, University Medical Center Hamburg-Eppendorf
City
Hamburg
Country
Germany
4
Last name
Spitzer
Initials of first name(s)
MS
Department
Department of Ophthalmology, University Medical Center Hamburg-Eppendorf
City
Hamburg
Country
Germany
5
Last name
Stübiger
Initials of first name(s)
N
Department
Department of Ophthalmology, University Medical Center Hamburg-Eppendorf
City
Hamburg
Country
Germany
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