Pediatric uveitis: a single-center 8-year pattern analysis in Reggio Emilia, Northern Italy.
Accept poster if oral is not possible ?
Yes
Purpose
To analyse the referral patterns and the clinical and therapeutic features of children diagnosed with uveitis in a tertiary referral center.
Methods
Retrospective retrieval of data incorporating all new pediatric referrals to the Immunology Ocular Unit in Reggio Emilia (Italy) from November 2015 to December 2023.
Results
Among the 263 patients, the male-to-female ratio was 1:1.32. Anterior uveitis was the most common (45.2%), followed by pan- (23.6%), intermediate (17.1%) and posterior (14.1%) uveitis. The most identifiable specific diagnoses were juvenile idiopathic arthritis (JIA) (27.8%), Vogt-Koyanagi-Harada disease (8.7%) and toxoplasmosis (7.6%). Non-infectious systemic disease aetiologies were the most frequent (47.1%), followed by infectious uveitis and non infectious ocular-specific conditions (both 15.6%). Idiopathic uveitis accounted for 34.6% of cases. Fuchs uveitis presented the longest mean diagnostic delay (54 months). Immunosuppressants were administrated in 77.6% of patients. Antimetabolites, calcineurin inhibitors and biologics were prescribed in 72.1%, 5.5% and 41.8% of cases, respectively. Metotrexate, adalimumab and azathioprine were the most commonly prescribed immunosuppressants (29.3%, 26.6% and 21.7% of patients, respectively). JIA-associated uveitis is the type of uveitis most commonly associated with surgical procedures (39.7%).
Conclusion
The patterns of uveitis in children are different from those in adults, with idiopathic uveitis accounting for the majority of cases and infectious aetiologies being less common. Nowadays, a wide range of immunosuppressants are used for the treatment of pediatric uveitis.
Conflict of interest
No
1
Last name
GENTILE
Initials of first name(s)
P
Department
Ocular Immunology Unit - AUSL IRCCS Reggio Emilia
City
Reggio Emilia
Country
Italy
2
Last name
CECCARELLI
Initials of first name(s)
F
Department
Ophthalmology Unit - University of Rome "Tor Vergata"
City
Rome
Country
Italy
3
Last name
ALDIGERI
Initials of first name(s)
R
Department
Department of Medicine and Surgery, University of Parma
City
Parma
Country
Italy
4
Last name
BOLLETTA
Initials of first name(s)
E
Department
Ocular Immunology Unit - AUSL IRCCS Reggio Emilia
City
Reggio Emilia
Country
Italy
5
Last name
DE SIMONE
Initials of first name(s)
L
Department
Ocular Immunology Unit - AUSL IRCCS Reggio Emilia
City
Reggio Emilia
Country
Italy
6
Last name
GOZZI
Initials of first name(s)
F
Department
Ocular Immunology Unit - AUSL IRCCS Reggio Emilia
City
Reggio Emilia
Country
Italy
7
Last name
CIMINO
Initials of first name(s)
L
Department
Ocular Immunology Unit - AUSL IRCCS Reggio Emilia
City
Reggio Emilia
Country
Italy
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