OCTA and Microperimetry in Behçet Retinal Vasculitis: Subgroup Analysis, Structure-Function Correlation, and 12-Month Follow-Up
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No
Purpose
Behçet's syndrome (BS) is mainly characterized by deep capillary plexus (DCP) damage in the macula detected on OCT angiography (OCTA). We further analyzed associations between macular structure/function, age, sex differences, and 12-month follow-up changes in inactive BS-associated retinal vasculitis.
Methods
Fourteen patients (23 eyes) with angiographic inactive BS-associated retinal vasculitis (mean age 40.6±11.7 years) were included and followed every 4 months. Retinal thickness, nerve fibers, ganglion cell layers on OCT; foveal avascular zone (FAZ) area, vascular density (VD) on OCTA; and macular sensitivity (MS) in microperimetry (MP) were analyzed. Data was compared between sex, age, and qualitative findings subgroups. Statistical analysis used generalized estimation equations and Spearman's correlation.
Results
Male sex, age <45 years, and qualitative findings (segmental absence of the perifoveal arcade, non-perfusion areas, and microvascular abnormalities) in any vascular plexus were associated (p<0.05) with pronounced quantitative findings in OCT/OCTA. VD respectively presented inverse and direct strong correlations (r>0.7) with FAZ area and retinal thickness. In the superficial vascular plexus (SVP), VD in the superior sector was directly associated with central MS (r=0.722; p<0.001). All biomarkers remained stable throughout the follow-up.
Conclusion
In BS-associated retinal vasculitis, male and young patients may present more severe structural and functional damage. Qualitative findings on OCT or OCTA, particularly SVP and intermediate capillary plexus involvement, were associated with structural and functional changes, denoting a more severe retinal disease.
Conflict of interest
No
1
Last name
FERREIRA
Initials of first name(s)
BFA
Department
Ophthalmology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
City
Sao Paulo
Country
Brazil
2
Last name
HIGASHI
Initials of first name(s)
AH
Department
Ophthalmology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
City
Sao Paulo
Country
Brazil
3
Last name
PRADO
Initials of first name(s)
LL
Department
Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
City
Sao Paulo
Country
Brazil
4
Last name
GONÇALVES
Initials of first name(s)
CR
Department
Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
City
Sao Paulo
Country
Brazil
5
Last name
HADDAD
Initials of first name(s)
MAO
Department
Ophthalmology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
City
Sao Paulo
Country
Brazil
6
Last name
RIBEIRO
Initials of first name(s)
AC
Department
Ophthalmology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
City
Sao Paulo
Country
Brazil
7
Last name
CARNEIRO
Initials of first name(s)
MA
Department
Ophthalmology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
City
Sao Paulo
Country
Brazil
8
Last name
ZACHARIAS
Initials of first name(s)
LC
Department
Ophthalmology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
City
Sao Paulo
Country
Brazil
9
Last name
MACHADO
Initials of first name(s)
CG
Department
Ophthalmology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
City
Sao Paulo
Country
Brazil
10
Last name
HIRATA
Initials of first name(s)
CE
Department
Ophthalmology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
City
Sao Paulo
Country
Brazil
11
Last name
YAMAMOTO
Initials of first name(s)
JH
Department
Ophthalmology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo
City
Sao Paulo
Country
Brazil
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