Distribution of Viral uveitis anterior over 12 years: A retrospective in Single-Center Study
Purpose
Infectious anterior uveitis is primarily caused by viral agents in many cases worldwide. The purpose of this study was to analyze the frequency, age, and gender distribution of viral uveitis anterior over a period of 12 years.
Methods
A retrospective chart review was conducted on patients who presented with suspected infectious uveitis between 2011 and 2022. Only patients who received an anterior chamber puncture (ACP) were included. The Goldman-Witmer-Coefficient (GWC) method was employed to detect and identify the respective causative viruses. Statistical analysis was performed using R-Script 4.2.3. (2023).
Results
A total of 2787 patients (=eyes) received an ACP within the last 12 years. Of these, 745 eyes were diagnosed with anterior uveitis caused by viral agents. The mean age was 50.36 years. The most common causative agents were herpes simplex virus (HSV) (n=442; 59.3%), varicella-zoster virus (VZV) (n=359; 48.2%), cytomegalovirus (CMV) (n=261; 35%), and rubella virus (RV) (n=278; 37.3%). There was a female preponderance for HSV (p < .05) and a male preponderance for CMV (p < .05). No significant gender difference was observed for VZV and RV. Most of the patients (n=371; 88.8%) had monocular involvement. Over the 12-year period, we observed a similar distribution of each virus.
Conclusion
The study provides important information on distribution of viral agents inducing uveitis anterior over a long time.
Conflict of interest
No
Authors 1
Last name
TSOGIA
Initials of first name(s)
F
Department
Charité - Universitätsmedizin Berlin Augenklinik / Department of Ophthalmology
City
Berlin
Country
Germany
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