MRI white matter abnormalities in children with non-infectious uveitis.
Purpose
The aim of this study is to analyse the prevalence of white matter abnormalities (WMA) in children with non-infectious uveitis (NIU). The presence of WMA in these children is important as they are now often treated with anti-TNFα therapy which could worsen pre-existing demyelinating white matter abnormalities.
Methods
From the University Medical Center Utrecht, medical records of children, <18 years old, with all types of NIU that underwent a cerebral MRI before starting anti-TNF-α treatment or on medical indication were analysed retrospectively. From the Meyer’s Children’s University Hospital Florence, the medical records of children, <18 years old, that underwent a cerebral MRI as part of their workup were analysed retrospectively.
Results
From two tertiary centers, the UMC Utrecht and the Meyer’s Children’s Hospital, a total of 112 children, 35 (31.3%) with anterior uveitis, 30 (26.8%) with intermediate uveitis, one with posterior uveitis (0.89%) and 46 (41.1%) with panuveitis, were included. A total of 29 children (25.9%) showed white matter abnormalities (WMA) on cerebral MRI. In addition, incidental findings included one patient with a glandula pinealis lesion, five patients with cysts, two patients with gliosis, one patient with optic neuritis, one patient with venous angioma, one patient with optic nerve atrophy and one patient with plexus papilloma.
In total, 78.0% of all MRI abnormal findings were seen in non-anterior uveitis patients.
Conclusion
In both tertiary centra, white matter abnormalities were frequently found on cerebral MRI, especially in non-anterior uveitis patients. Typically these abnormalities were asymptomatic.
Conflict of interest
No
Authors 1
Last name
HENDRIKSE
Initials of first name(s)
J
Department
Ophthalmology
City
Utrecht
Country
Netherlands
Authors 2
Last name
Maccora
Initials of first name(s)
I
Department
Rheumatology
City
Florence
Country
Italy
Authors 3
Last name
Koopman-Kalinina Ayuso
Initials of first name(s)
V
Department
Ophthalmology
City
Utrecht
Country
Netherlands
Authors 4
Last name
Brandsma
Initials of first name(s)
R
Department
Pediatric Neurology
City
Utrecht
Country
Netherlands
Authors 5
Last name
Jansen
Initials of first name(s)
MH
Department
Immunology
City
Utrecht
Country
Netherlands
Authors 6
Last name
Nievelstein
Initials of first name(s)
RAJ
Department
Radiology and Nuclear Medicine
City
Utrecht
Country
Netherlands
Authors 7
Last name
Kuiper
Initials of first name(s)
JJW
Department
Translational Immunology
City
Utrecht
Country
Netherlands
Authors 8
Last name
Simonini
Initials of first name(s)
G
Department
Rheumatology
City
Florence
Country
Italy
Authors 9
Last name
de Boer
Initials of first name(s)
JH
Department
Ophthalmology
City
Utrecht
Country
Netherlands
This website uses cookies to ensure you get the best experience on our website.
Learn more