Anterior vitreous inflammatory changes seen on SS-ASOCT
Purpose
To assess inflammatory changes in the anterior vitreous (AV) using a swept source anterior segment optical coherence tomography (SS-ASOCT) and to correlate them with uveitis features and clinical grading of intraocular inflammation.
Methods
140 eyes from 96 patients were included: 40 ACTIVE uveitis, 40 INACTIVE uveitis and 60 CONTROLS. All eyes underwent intraocular inflammation clinical grading (anterior chamber (AC) cells counting and vitreous haze evaluation) and AV imaging with SS-ASOCT. Cells seen in the AV on OCT were manually counted using imageJ. Vitreous reflectivity variation was indirectly measured by calculating the vitreous/iris pigment epithelium (VIT/IPE) relative intensity. These OCT-based parameters were compared across the groups and correlated with inflammation clinical grading.
Results
The mean[SD] number of AV OCT cells was significantly higher (both p<0.001) in ACTIVE uveitis (12[9.8]) compared to INACTIVE uveitis (4.5[3.5]) and CONTROLS (4[3.1]). In ACTIVE uveitis the number of AV OCT cells was significantly and positively correlated with the AC cells (p=0.04), the VIT/IPE relative intensity (p=0.0002), the uveitis anatomical classification (INTERMEDIATE UVEITIS, p=0.02) and the vitreous haze clinical grading (p<0.0001). The mean[SD] VIT/IPE relative intensity of the AV increased from CONTROLS (0.12[0.01]) to INACTIVE uveitis (0.15[0.01]) to ACTIVE uveitis (0.17[0.02]), but with no statistically significant differences.
Conclusion
We were able to visualize and objectively evaluate changes occurring in the AV in eyes with uveitis by means of a commercially available SS-ASOCT. OCT-cells in the AV could represent an adjunctive tool in the objective evaluation of intraocular inflammation.
Conflict of interest
Yes
Details of conflicting interests
Alessandro invernizzi has received personal fees from Heidelberg engineering, Roche, Novartis, Bayer outside the submitted work
Authors 1
Last name
INVERNIZZI
Initials of first name(s)
A
Department
Department of Biomedical and Clinical Science, University of Milan, Milan, Italy
City
MILAN
Country
Italy
Authors 2
Last name
Zaffalon
Initials of first name(s)
C
Department
Ophthalmic Unit, Department of Neurosciences, Biomedicine and Movement Sciences, University of Ve
City
VERONA
Country
Italy
Authors 3
Last name
Manni
Initials of first name(s)
P
Department
Department of Sense Organs, Ocular Immunovirology Service, Sapienza University of Rome, Rome, Ita
City
ROME
Country
Italy
Authors 4
Last name
Zicarelli
Initials of first name(s)
F
Department
Department of Biomedical and Clinical Science, University of Milan, Milan, Italy
City
MILAN
Country
Italy
Authors 5
Last name
Staurenghi
Initials of first name(s)
G
Department
Department of Biomedical and Clinical Science, University of Milan, Milan, Italy
City
MILAN
Country
Italy
Authors 6
Last name
Gozzi
Initials of first name(s)
F
Department
Ocular Immunology Unit, Azienda USL-IRCCS of Reggio Emilia, Reggio Emilia, Italy
City
Reggio Emilia
Country
Italy
Authors 7
Last name
Mastrofilippo
Initials of first name(s)
V
Department
Ocular Immunology Unit, Azienda USL-IRCCS of Reggio Emilia, Reggio Emilia, Italy
City
Reggio Emilia
Country
Italy
Authors 8
Last name
Bolletta
Initials of first name(s)
E
Department
Ocular Immunology Unit, Azienda USL-IRCCS of Reggio Emilia, Reggio Emilia, Italy
City
Reggio Emilia
Country
Italy
Authors 9
Last name
De Simone
Initials of first name(s)
L
Department
Ocular Immunology Unit, Azienda USL-IRCCS of Reggio Emilia, Reggio Emilia, Italy
City
Reggio Emilia
Country
Italy
Authors 10
Last name
Cimino
Initials of first name(s)
L
Department
Department of Surgery, Medicine, Dentistry and Morphological Sciences, with Interest in Transplan
City
Reggio Emilia
Country
Italy
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