The use of electrophysiology to augment multimodal imaging in inflammatory choroidopathies
Purpose
To further highlight where electrodiagnosis augments our multimodal imaging in a spectrum of White Dot Syndromes.
Methods
A retrospective case series of patients seen at the Uveitis unit at Sydney Eye Hospital and Electrophysiology department at Save Sight Institute between 2005-2019. Data pertaining to clinical history, examination, multimodal imaging, electrophysiology findings and treatment modalities was collected.
Results
115 patients (190 eyes) were included. Diagnoses included Multifocal Choroiditis with Panuveitis (MFCPU) (31.3%), Acute Zonal Occult Outer Retinopathy (AZOOR) (29.6%), Birdshot Chorioretinopathy (BCR) (14.8%), Punctate Inner Choroidopathy (PIC) (12.2%) and Multiple Evanescent White Dot Syndrome (MEWDS) (4.3%). The average age was 40.9 years. The majority of patients were female (67%), Caucasian (77.4%) and had bilateral ocular involvement (65.2%). Mean visual acuity was 20/60 at initial review and 20/40 at final review. MCFPU, AZOOR, BCR and PIC accounted for 93.8% of 65 WDS patients that underwent electrophysiology. Electrophysiology helped confirm the final diagnosis in 97.1% of AZOOR and 88.2% of BCR (p=.000073).
Conclusion
This study highlights how clinical findings and multimodal imaging are sufficient to diagnose MFCPU and PIC. Electrophysiology is needed to diagnose, monitor treatment response and inform the visual prognosis in patients with AZOOR and BCR.
Conflict of interest
No
Authors 1
Last name
LIM
Initials of first name(s)
B
Department
Save Sight Institute - University of Sydney (SSI - USYD), Sydney Eye Hospital (SEH)
City
Sydney
Country
Australia
Authors 2
Last name
Zagora
Initials of first name(s)
S
Department
SSI - USYD, SEH
City
Sydney
Country
Australia
Authors 3
Last name
Cornish
Initials of first name(s)
E
Department
SSI - USYD, SEH
City
Sydney
Country
Australia
Authors 4
Last name
Grigg
Initials of first name(s)
J
Department
SSI - USYD, SEH
City
Sydney
Country
Australia
Authors 5
Last name
McCluskey
Initials of first name(s)
P
Department
SSI - USYD, SEH
City
Sydney
Country
Australia
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