This abstract is assigned to sessions
| Presentation preference | Poster and Rapid fire |
| Title | The paradigm shift of the treatment for Paediatric uveitis - the use of disease modifying biologics |
| Accept poster if oral is not possible ? | Yes |
| Purpose | Paediatric uveitis may have a debilitating impact upon children due to treatment failure and disease progression resulting in Paediatric Cataract and Glaucoma. Biologic agents are a relatively new treatment with promising outcomes. Traditionally corticosteroids (both topical and oral) and immunosuppressive agents such as methotrexate were used for the treatment of uveitis. |
| Methods | Retrospective, chart review demographic data, treatment efficacy, failure and safety over an 8-year period of 27 paediatric uveitis patients (49 eyes) at a quaternary referral eye hospital in Sydney, Australia treated with biologic agents followed up to 1 year were included. |
| Results | Of the 27 patients (49 eyes), 43% had increased IOP, 40% Cataract and 25% some form of glaucomatous optic neuropathy at presentation. Biologic therapy over 1 year was effective with prednisolone reduced to <5mg/day in 5 of 6 patients (83%), systemic steroid-sparing agents was reduced to ≤ 1 in 2 of 4 patients (50%), and cessation of topical steroid achieved in 12 of 41 of eyes (29%). Cessation of topical steroids was achieved in 7/45 eyes (16% (95% CI, 7.7-28.8)) at 6 weeks of follow-up, 10/43 eyes (23% (95% CI, 13.2-37.7)) at 6 months of follow-up, and 12/41 eyes (29% (95% CI, 17.6-44.5)) at 12 months of follow-up. |
| Conclusion | Biologic therapy was demonstrated to be effective and safe in paediatric uveitis in the real-world setting. It resulted in reduction of corticosteroid burden, and number of steroid-sparing agents. |
| Conflict of interest | No |
Author 1
| Last name | ZAGORA |
| Initials of first name(s) | SL |
| Department | Discipline of Ophthalmology, University of Sydney |
| City | Sydney |
| Country | Australia |
Author 2
| Last name | Oh |
| Initials of first name(s) | L |
| Department | Discipline of Ophthalmology, University of Sydney |
| City | Sydney |
| Country | Australia |
Author 3
| Last name | McCluskey |
| Initials of first name(s) | PM |
| Department | Discipline of Ophthalmology, University of Sydney |
| City | Sydney |
| Country | Australia |
