| Presentation preference | Oral presentation |
| Title | Virus-associated anterior uveitis and secondary glaucoma |
| Accept poster if oral is not possible ? | Yes |
| Purpose | Compare clinical characteristics and analyze glaucoma development/surgery requirements in patients with different virus-associated anterior uveitis (VAU). |
| Methods | Study of 270 patients with VAU confirmed by positive Goldmann-Witmer-coefficients(GWC) for cytomegalovirus(CMV), herpes simplex virus(HSV), varicella-zoster virus(VZV), rubella virus(RV), & multiple-viruses(MV).Demographic constitution, clinical findings, glaucoma development, and surgeries were recorded. |
| Results | GWC analysis showed positive results for CMV(21%), HSV(29%), VZV(17%), RV(29%), and MV(5%). CMV and RV AU occur predominantly in younger/male patients, while VZV and HSV AU appeared in elderly/females. Unilateral involvement was typical for almost all viruses(76-98%), but 24% of VZV also showed bilateral manifestation. Course of disease was mainly acute for CMV(96%), while chronic disease was observed in RV(84%) and in HSV(68%). Differences like iris synechia, vitreous haze, and macular edema were noted. In total, 19% showed glaucomatous damage and 10% needed glaucoma surgery. Minimal-invasive glaucoma surgery resulted in a reliable IOP reduction in short-term period. In 37% first surgical intervention failed, and a follow-up surgery was required. |
| Conclusion | Different virus entities show common clinical findings. To establish an appropriate treatment, it is important to confirm the diagnosis by GWC. Otherwise, development of secondary glaucoma as a serious complication of uveitis is inevitable. It is crucial to choose distinctive therapeutic approaches like appropriate surgical interventions to avoid vision-threatening complications. |
| Conflict of interest | No |
Author 1
| Last name | POHLMANN |
| Initials of first name(s) | D |
| Department | Ophthalmology, Charité |
| City | Berlin |
| Country | Germany |
Author 2
| Last name | Pahlitzsch |
| Initials of first name(s) | M |
| Department | Charité |
| City | Berlin |
| Country | Germany |
Author 3
| Last name | Winterhalter |
| Initials of first name(s) | S |
| Department | Charité |
| City | Berlin |
| Country | Germany |
Author 4
| Last name | Pleyer |
| Initials of first name(s) | U |
| Department | Charité |
| City | Berlin |
| Country | Germany |
