Evaluation of Toxoplasma antibodies level in patients with Ocular Toxoplasmosis in DR Congo
Accept poster if oral is not possible ?
Yes
Purpose
To determine the relationship between OT and levels of Toxoplasma IgG antibodies in patients with uveitis.
Methods
190 patients with uveitis underwent a complete ophthalmological examination and anti-Toxoplasma serology (Ig G) by enzyme-linked fluorescent assay (ELFA, Biomerieux, France). The patients were distributed in 2 groups: those with OT (= group 1) and those with uveitis of other etiologies (= group 2). The IgG level was compared according to sex, age, etiology of uveitis (group 1 and 2), type of OT, and clinical characteristics of OT using the Mann-Whitney non-parametric test.
Results
88 patients (46.3%) were included in group 1, and 102 patients (53.7%) in group 2. Patients in group 1 were younger than those in group 2 (mean age ±SD: 36.4±14.4 years VS 46.3±15.9 years, P<0.001). The median IgG level was higher in patients with OT than in group 2 (214.5 IU/ml VS 59.5 IU/ml, P<0.001). Among cases of active OT, patients with primary OT had a higher median IgG level than those with recurrence (295 IU/ml VS 181 IU/ml, P=0.006). No difference was found in the IgG level depending on the sex and age of the patients, the laterality of the ocular involvement, the location, the number, and the size of the chorioretinitis lesions (P> 0.05).
Conclusion
An increase in the serum level of IgG anti-Toxoplasma antibodies was found in OT cases, with a greater elevation during primary OT than during recurrences. The level of antibodies seems to have no relationship with the clinical characteristics of the pathology.
Conflict of interest
No
1
Last name
NSIANGANI LUSAMBO
Initials of first name(s)
N
Department
Department of Ophthalmology, Teaching Hospital, University of Kinshasa
City
Kinshasa
Country
R.D. du Congo
2
Last name
KAIMBO WA KAIMBO
Initials of first name(s)
D
Department
Department of Ophthalmology, Teaching Hospital, University of Kinshasa
City
Kinshasa
Country
R.D. du Congo
3
Last name
de-la-Torre
Initials of first name(s)
A
Department
2Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Institute of Translational Medici
City
Bogota
Country
Colombia
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