Risk of uveitis among E-Cigarette Users: a multi-institutional TriNetX study
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Purpose
Electronic cigarettes (e-cigarettes) are devices that produce a heated aerosol from nicotine-containing e-liquid. Sputum from e-cigarette users have been found to contain increased levels of oxidative stress-related proteins, which have been previously implicated in the development of uveitis. However, no multi-institutional retrospective study has investigated the risk of uveitis among adults using e-cigarettes. TriNetX platform was used to examine the risk of uveitis among e-cigarette users.
Methods
The TriNetX database was used to recruit adult patients with and without a history of e-cigarette usage. The primary outcome was the incidence of new-onset uveitis.
Results
E-cigarette users were associated with an increased risk for uveitis compared to non-users (HR: 2.53). Subgroup analysis revealed an increased risk of uveitis among e-cigarette users aged 18-39 years (HR: 2.59), 40-64 years (HR: 2.20) and ≥65 years (HR: 3.15). Further subgroup analysis revealed an increased uveitis risk among cigarette-only users compared to non-cigarette users (HR: 1.28). An increased risk for uveitis was seen in the subgroup analysis: among those with a dual history of e-cigarette and traditional cigarette users compared to traditional cigarette-only users (HR: 1.39), among users who had a dual history (HR: 1.35) compared to those who never had a history of e-cigarettes, and among e-cigarette users compared to those with a dual history (HR: 1.84).
Conclusion
An increased risk for uveitis was seen among e-cigarette users compared to non-users. This study has real-world implications as clinicians caring for patients with e-cigarette history should be aware of the potentially increased risk of new-onset uveitis.
Conflict of interest
No
1
Last name
LIN
Initials of first name(s)
CJ
Department
Department of Ophthalmology, China Medical University Hospital, Taiwan
City
Taichung
Country
Taiwan
2
Last name
HSU
Initials of first name(s)
A
Department
Department of Ophthalmology, China Medical University Hospital, Taiwan
City
Taichung
Country
Taiwan
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