Infections Presenting as Tumor- Reverse Masquerade Syndromes
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Yes
Purpose
Ocular infections may rarely present as neoplasms. We report 5 cases of infections of the eye presenting as mass lesions mimicking tumors.
Methods
Retrospective analysis of 5 cases that presented as tumors, and later turned out to be infective in nature. This was confirmed by histopathology, microbiology and molecular biology studies.
Results
First case was a conjunctival tuberculoma suspected to be a conjunctival squamous cell carcinoma. Histopathology showed Acid Fast Bacilli on Ziehl Neelsen stain and PCR (Polymerase Chain Reaction) of the paraffin section showed Mycobacterium TB DNA. The second case presented as a scleral mass. Laboratory investigations were positive for VDRL and TPHA and responded to syphilis treatment. The third case presented as an amelanotic melanoma. Enucleated specimen on histopathology showed severe scleral inflammation suggestive of posterior scleritis and PCR was positive for Mycobacterium TB DNA. The fourth case presented as a ciliary body mass with choroidal granuloma. PCR of vitreous aspirate was positive for mycobacterium TB DNA. The fifth case presented with a vascularized iris root mass. Potassium hydroxide staining showed fungal filaments with Aspergillus fumigatus and PCR confirmed the presence of a panfungal genome.
Conclusion
Ocular infections can masquerade as tumors. Histopathology, microbiology and molecular biologic studies can confirm the diagnosis.
Conflict of interest
No
1
Last name
MATHEW
Initials of first name(s)
N R
Department
Uvea and Medical Retina
City
Chennai
Country
India
2
Last name
Biswas
Initials of first name(s)
J
Department
Uvea and Ocular Pathology
City
Chennai
Country
India
3
Last name
Janakiraman
Initials of first name(s)
P
Department
Uvea
City
Chennai
Country
India
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