Presumed tuberculosis-associated uveitis: clinical characteristics and response to antitubercular therapy
Purpose
To report the clinical presentation and treatment outcomes of patients with presumed tuberculosis-associated uveitis.
Methods
Retrospective case series including patients with possible or probable intraocular tuberculosis from a single centre in Portugal. All patients were treated with appropriate antitubercular therapy (ATT) combined with corticosteroids and/or immunosuppression. Medical records were reviewed for the patient’s demographics and clinical data. The response to therapy was assessed at 12-months follow-up.
Results
A total of 17 patients were included. Median age at diagnosis was 53 years (range 11-73), and 58.8% of patients were female. Eight patients had bilateral uveitis. The most common clinical phenotypes were bilateral anterior uveitis (41.2%) and intermediate uveitis (29.4%). Five patients (29.4%) underwent concurrent oral corticosteroid therapy and three (17.6%) received immunosuppression with cyclosporine. Best-corrected visual acuity improved significantly from baseline (0.2 logMAR, range 0-0.7) to 12-months follow-up (0.1 logMAR, range 0-0.7; p=0.045). Resolution of intraocular inflammation, with or without adjuvant corticosteroid therapy and/or immunosuppression, was noted in 82.3% of patients at 12-months follow-up. Complete resolution at 12-months follow-up, defined by the absence of intraocular inflammation and discontinuation of all treatment, was achieved in 12 patients (70.6%).
Conclusion
Diagnosis and management of presumed tuberculosis-associated uveitis can be challenging. In this study, we add further evidence for the efficacy of ATT combined with adjuvant therapy for adequate control of intraocular inflammation in these patients.
Conflict of interest
No
Authors 1
Last name
FERREIRA
Initials of first name(s)
C.
Department
Department of Ophthalmology, Centro Hospitalar Vila Nova de Gaia/Espinho
City
Vila Nova de Gaia
Country
Portugal
Authors 2
Last name
CABANAS
Initials of first name(s)
J.
Department
Department of Ophthalmology, Centro Hospitalar Vila Nova de Gaia/Espinho
City
Vila Nova de Gaia
Country
Portugal
Authors 3
Last name
FONSECA
Initials of first name(s)
S.
Department
Department of Ophthalmology, Centro Hospitalar Vila Nova de Gaia/Espinho
City
Vila Nova de Gaia
Country
Portugal
This website uses cookies to ensure you get the best experience on our website.
Learn more