View abstract

This abstract is assigned to session Free Papers Session 2

Presentation preference	Oral presentation
Title	Anterior vitreous inflammatory changes seen on SS-ASOCT

Purpose	To assess inflammatory changes in the anterior vitreous (AV) using a swept source anterior segment optical coherence tomography (SS-ASOCT) and to correlate them with uveitis features and clinical grading of intraocular inflammation.
Methods	140 eyes from 96 patients were included: 40 ACTIVE uveitis, 40 INACTIVE uveitis and 60 CONTROLS. All eyes underwent intraocular inflammation clinical grading (anterior chamber (AC) cells counting and vitreous haze evaluation) and AV imaging with SS-ASOCT. Cells seen in the AV on OCT were manually counted using imageJ. Vitreous reflectivity variation was indirectly measured by calculating the vitreous/iris pigment epithelium (VIT/IPE) relative intensity. These OCT-based parameters were compared across the groups and correlated with inflammation clinical grading.
Results	The mean[SD] number of AV OCT cells was significantly higher (both p<0.001) in ACTIVE uveitis (12[9.8]) compared to INACTIVE uveitis (4.5[3.5]) and CONTROLS (4[3.1]). In ACTIVE uveitis the number of AV OCT cells was significantly and positively correlated with the AC cells (p=0.04), the VIT/IPE relative intensity (p=0.0002), the uveitis anatomical classification (INTERMEDIATE UVEITIS, p=0.02) and the vitreous haze clinical grading (p<0.0001). The mean[SD] VIT/IPE relative intensity of the AV increased from CONTROLS (0.12[0.01]) to INACTIVE uveitis (0.15[0.01]) to ACTIVE uveitis (0.17[0.02]), but with no statistically significant differences.
Conclusion	We were able to visualize and objectively evaluate changes occurring in the AV in eyes with uveitis by means of a commercially available SS-ASOCT. OCT-cells in the AV could represent an adjunctive tool in the objective evaluation of intraocular inflammation.
Conflict of interest	Yes
Details of conflicting interests	Alessandro invernizzi has received personal fees from Heidelberg engineering, Roche, Novartis, Bayer outside the submitted work

Authors 1

Last name	INVERNIZZI
Initials of first name(s)	A
Department	Department of Biomedical and Clinical Science, University of Milan, Milan, Italy
City	MILAN
Country	Italy

Authors 2

Last name	Zaffalon
Initials of first name(s)	C
Department	Ophthalmic Unit, Department of Neurosciences, Biomedicine and Movement Sciences, University of Ve
City	VERONA
Country	Italy

Authors 3

Last name	Manni
Initials of first name(s)	P
Department	Department of Sense Organs, Ocular Immunovirology Service, Sapienza University of Rome, Rome, Ita
City	ROME
Country	Italy

Authors 4

Last name	Zicarelli
Initials of first name(s)	F
Department	Department of Biomedical and Clinical Science, University of Milan, Milan, Italy
City	MILAN
Country	Italy

Authors 5

Last name	Staurenghi
Initials of first name(s)	G
Department	Department of Biomedical and Clinical Science, University of Milan, Milan, Italy
City	MILAN
Country	Italy

Authors 6

Last name	Gozzi
Initials of first name(s)	F
Department	Ocular Immunology Unit, Azienda USL-IRCCS of Reggio Emilia, Reggio Emilia, Italy
City	Reggio Emilia
Country	Italy

Authors 7

Last name	Mastrofilippo
Initials of first name(s)	V
Department	Ocular Immunology Unit, Azienda USL-IRCCS of Reggio Emilia, Reggio Emilia, Italy
City	Reggio Emilia
Country	Italy

Authors 8

Last name	Bolletta
Initials of first name(s)	E
Department	Ocular Immunology Unit, Azienda USL-IRCCS of Reggio Emilia, Reggio Emilia, Italy
City	Reggio Emilia
Country	Italy

Authors 9

Last name	De Simone
Initials of first name(s)	L
Department	Ocular Immunology Unit, Azienda USL-IRCCS of Reggio Emilia, Reggio Emilia, Italy
City	Reggio Emilia
Country	Italy

Authors 10

Last name	Cimino
Initials of first name(s)	L
Department	Department of Surgery, Medicine, Dentistry and Morphological Sciences, with Interest in Transplan
City	Reggio Emilia
Country	Italy