Prognostic factors for the introduction of biological therapy in patients with juvenile idiopathic arthritis-related uveitis
Purpose
Purpose of this retrospective study was to clinically characterize a cohort of patients with juvenile idiopathic arthritis(JIA) related uveitis and identify prognostic factors present at JIA onset that may predict the need for administering biologicals for uveitis control.
Methods
The study was conducted at the Clinical Rheumatology Units of IRCCS Foundation Ca’ Granda Ospedale Maggiore Policlinico and at ASST Gaetano Pini, Milan, Italy between January 2002 and December 2020. Clinical data was collected from patients’ charts, including the type of arthritis, laterality of uveitis, ophthalmic complications at the first presentation, erythrocyte sedimentation rate, and C reactive protein levels.
Cox regression analysis was performed to determine whether any of the collected parameters were associated with the need for administering biological therapy for uveitis control.
Results
A total of 99 patients (82 females; mean age at JIA onset: 3.88±3.11 years) were included in the study. Of these, 25 had a polyarticular disease and 35 had bilateral uveitis. All patients received disease-modifying antirheumatic drugs. During the follow-up period (mean 9.15±4.71 years), 65 patients required the introduction of biological therapy to control the uveitis.
A higher risk of requiring biological therapy was associated with oligoarticular disease (hazard ratio [HR]: 2.05; 95% confidence interval [CI]: 1.19-3.54, p=0.010) and a longer time between the onset of JIA and the onset of uveitis (HR: 1.11; 95% CI: 1.03-1.2, p=0.007).
Conclusion
These findings could potentially assist clinicians in identifying patients who may require more aggressive treatment strategies to manage their disease.
Conflict of interest
No
Authors 1
Last name
MAPELLI
Initials of first name(s)
C
Department
Ophtalmology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico
City
Milan
Country
Italy
Authors 2
Last name
MISEROCCHI
Initials of first name(s)
E
Department
Ocular Immunology and Uveitis Service Department of Ophthalmology. San Raffaele Scientific Institute
City
Milan
Country
Italy
Authors 3
Last name
BERETTA
Initials of first name(s)
GB
Department
Pediatric Rheumatology Pediatric Intermediate Care Unit Fondazione IRCCS Ca’Granda Ospedale Maggiore
City
Milan
Country
Italy
Authors 4
Last name
MARELLI
Initials of first name(s)
L
Department
Eye Clinic San Giuseppe Hospital, IRCCS Multimedica Scientif Institute
City
Milan
Country
Italy
Authors 5
Last name
LEONE
Initials of first name(s)
G
Department
Ophtalmology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico
City
Milan
Country
Italy
Authors 6
Last name
FILOCAMO
Initials of first name(s)
G
Department
Pediatric Rheumatology Pediatric Intermediate Care Unit Fondazione IRCCS Ca’Granda Ospedale Maggiore
City
Milan
Country
Italy
Authors 7
Last name
VIOLA
Initials of first name(s)
F
Department
Ophtalmology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico
City
Milan
Country
Italy
Authors 8
Last name
NASSISI
Initials of first name(s)
M
Department
Ophtalmology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico
City
Milan
Country
Italy
Authors 9
Last name
MINOIA
Initials of first name(s)
F
Department
Pediatric Rheumatology Pediatric Intermediate Care Unit Fondazione IRCCS Ca’Granda Ospedale Maggiore
City
Milan
Country
Italy
This website uses cookies to ensure you get the best experience on our website.
Learn more